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A Mechanistic View of Enzyme Inhibition and Peptide Hydrolysis in the Active Site of the SARS-CoV 3C-like Peptidase

The 3C-like main peptidase 3CL(pro) is a viral polyprotein processing enzyme essential for the viability of the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV). While it is generalized that 3CL(pro) and the structurally related 3C(pro) viral peptidases cleave their substrates via a mechanis...

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Detalles Bibliográficos
Autores principales:	Yin, Jiang, Niu, Chunying, Cherney, Maia M., Zhang, Jianmin, Huitema, Carly, Eltis, Lindsay D., Vederas, John C., James, Michael N.G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2007
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094781/ https://www.ncbi.nlm.nih.gov/pubmed/17599357 http://dx.doi.org/10.1016/j.jmb.2007.06.001

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