HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway

Hepatocellular carcinoma (HCC) is one of the most common human cancers, its prevalence and severity need us to discover novel early diagnostic biomarkers and new therapeutic strategies. MicroRNA-122 is the most abundant microRNA in the liver, and acts as a tumor suppressor and represses HCC developm...

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Autores principales: Yang, Guang, Zhang, Min, Zhao, Yawei, Pan, Yue, Kan, Mujie, Li, Jing, He, Kan, Zhang, Xuewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094838/
https://www.ncbi.nlm.nih.gov/pubmed/32210451
http://dx.doi.org/10.1371/journal.pone.0230450
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author Yang, Guang
Zhang, Min
Zhao, Yawei
Pan, Yue
Kan, Mujie
Li, Jing
He, Kan
Zhang, Xuewen
author_facet Yang, Guang
Zhang, Min
Zhao, Yawei
Pan, Yue
Kan, Mujie
Li, Jing
He, Kan
Zhang, Xuewen
author_sort Yang, Guang
collection PubMed
description Hepatocellular carcinoma (HCC) is one of the most common human cancers, its prevalence and severity need us to discover novel early diagnostic biomarkers and new therapeutic strategies. MicroRNA-122 is the most abundant microRNA in the liver, and acts as a tumor suppressor and represses HCC development. In our study we showed that HNF-4α and MiR-122 were down-regulated significantly in hepatocellular carcinoma. Over-expression of HNF-4α inhibit hepatocellular carcinoma cells proliferation. And miR-122 is one of the downstream effector of HNF-4α. Up-regulated miR-122 inhibited hepatocellular carcinoma cells proliferation through regulating ADAM17. Collectively, our results suggested that HNF-4α could inhibit hepatocellular carcinoma proliferation with miR-122 being a downstream target of it. And miR-122 would inhibit hepatocellular carcinoma proliferation by regulating ADAM17 signal pathway.
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spelling pubmed-70948382020-04-03 HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway Yang, Guang Zhang, Min Zhao, Yawei Pan, Yue Kan, Mujie Li, Jing He, Kan Zhang, Xuewen PLoS One Research Article Hepatocellular carcinoma (HCC) is one of the most common human cancers, its prevalence and severity need us to discover novel early diagnostic biomarkers and new therapeutic strategies. MicroRNA-122 is the most abundant microRNA in the liver, and acts as a tumor suppressor and represses HCC development. In our study we showed that HNF-4α and MiR-122 were down-regulated significantly in hepatocellular carcinoma. Over-expression of HNF-4α inhibit hepatocellular carcinoma cells proliferation. And miR-122 is one of the downstream effector of HNF-4α. Up-regulated miR-122 inhibited hepatocellular carcinoma cells proliferation through regulating ADAM17. Collectively, our results suggested that HNF-4α could inhibit hepatocellular carcinoma proliferation with miR-122 being a downstream target of it. And miR-122 would inhibit hepatocellular carcinoma proliferation by regulating ADAM17 signal pathway. Public Library of Science 2020-03-25 /pmc/articles/PMC7094838/ /pubmed/32210451 http://dx.doi.org/10.1371/journal.pone.0230450 Text en © 2020 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yang, Guang
Zhang, Min
Zhao, Yawei
Pan, Yue
Kan, Mujie
Li, Jing
He, Kan
Zhang, Xuewen
HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway
title HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway
title_full HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway
title_fullStr HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway
title_full_unstemmed HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway
title_short HNF-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway
title_sort hnf-4α inhibits hepatocellular carcinoma cell proliferation through mir-122-adam17 pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094838/
https://www.ncbi.nlm.nih.gov/pubmed/32210451
http://dx.doi.org/10.1371/journal.pone.0230450
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