Cargando…
No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression
BACKGROUND: Non-muscle invasive bladder cancer patients are at high risk for tumour recurrence and progression, hence an intensive follow-up procedure is recommended which is costly. Identification of factors that are associated with the risk of recurrence and progression may enable personalized fol...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094867/ https://www.ncbi.nlm.nih.gov/pubmed/32210471 http://dx.doi.org/10.1371/journal.pone.0229384 |
_version_ | 1783510549479292928 |
---|---|
author | Evers, Jelle Grotenhuis, Anne J. Aben, Katja K. H. Kiemeney, Lambertus A. L. M. Vrieling, Alina |
author_facet | Evers, Jelle Grotenhuis, Anne J. Aben, Katja K. H. Kiemeney, Lambertus A. L. M. Vrieling, Alina |
author_sort | Evers, Jelle |
collection | PubMed |
description | BACKGROUND: Non-muscle invasive bladder cancer patients are at high risk for tumour recurrence and progression, hence an intensive follow-up procedure is recommended which is costly. Identification of factors that are associated with the risk of recurrence and progression may enable personalized follow-up schedules. Obesity and diabetes mellitus may be associated with a worse prognosis, but the evidence is limited and inconsistent. Our objective was to determine the associations of BMI and diabetes mellitus with risks of recurrence and progression among non-muscle invasive bladder cancer patients. METHODS: A population-based cohort of patients diagnosed with non-muscle invasive bladder cancer between 1995 and 2010 was retrospectively identified from the Netherlands Cancer Registry and invited to participate in the Nijmegen Bladder Cancer Study (n = 1,433). Average weight during adult life, height, and diabetes mellitus diagnosis were self-reported by use of a questionnaire. Clinical follow-up data were retrieved from medical files. Associations were quantified using proportional hazard analyses. For all analyses, minimal adjustment sets were selected using a Directed Acyclic Graph. RESULTS: Fourteen percent of the patients indicated to be diagnosed with diabetes mellitus, and more than half was overweight (45%) or obese (9%). Compared to healthy weight, overweight and obesity were not associated with risk of recurrence (adjusted hazard ratio (HR) = 1.02; 95% confidence interval (CI): 0.86–1.22, and HR = 1.02; 95% CI: 0.76–1.38, respectively) and overall progression (HR = 1.04; 95% CI: 0.74–1.44, and HR = 1.20; 95% CI: 0.69–2.09, respectively). Also, no clear associations of diabetes mellitus with risk of recurrence (HR = 1.22; 95% CI: 0.98–1.54) and overall progression (HR = 1.16; 95% CI: 0.76–1.76) were found. CONCLUSION: Average BMI during adult life and diabetes mellitus were not clearly associated with risk of recurrence or progression in non-muscle invasive bladder cancer. Prospective cohort studies with detailed information on BMI and diabetes mellitus before and after diagnosis are needed to confirm these findings. |
format | Online Article Text |
id | pubmed-7094867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-70948672020-04-03 No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression Evers, Jelle Grotenhuis, Anne J. Aben, Katja K. H. Kiemeney, Lambertus A. L. M. Vrieling, Alina PLoS One Research Article BACKGROUND: Non-muscle invasive bladder cancer patients are at high risk for tumour recurrence and progression, hence an intensive follow-up procedure is recommended which is costly. Identification of factors that are associated with the risk of recurrence and progression may enable personalized follow-up schedules. Obesity and diabetes mellitus may be associated with a worse prognosis, but the evidence is limited and inconsistent. Our objective was to determine the associations of BMI and diabetes mellitus with risks of recurrence and progression among non-muscle invasive bladder cancer patients. METHODS: A population-based cohort of patients diagnosed with non-muscle invasive bladder cancer between 1995 and 2010 was retrospectively identified from the Netherlands Cancer Registry and invited to participate in the Nijmegen Bladder Cancer Study (n = 1,433). Average weight during adult life, height, and diabetes mellitus diagnosis were self-reported by use of a questionnaire. Clinical follow-up data were retrieved from medical files. Associations were quantified using proportional hazard analyses. For all analyses, minimal adjustment sets were selected using a Directed Acyclic Graph. RESULTS: Fourteen percent of the patients indicated to be diagnosed with diabetes mellitus, and more than half was overweight (45%) or obese (9%). Compared to healthy weight, overweight and obesity were not associated with risk of recurrence (adjusted hazard ratio (HR) = 1.02; 95% confidence interval (CI): 0.86–1.22, and HR = 1.02; 95% CI: 0.76–1.38, respectively) and overall progression (HR = 1.04; 95% CI: 0.74–1.44, and HR = 1.20; 95% CI: 0.69–2.09, respectively). Also, no clear associations of diabetes mellitus with risk of recurrence (HR = 1.22; 95% CI: 0.98–1.54) and overall progression (HR = 1.16; 95% CI: 0.76–1.76) were found. CONCLUSION: Average BMI during adult life and diabetes mellitus were not clearly associated with risk of recurrence or progression in non-muscle invasive bladder cancer. Prospective cohort studies with detailed information on BMI and diabetes mellitus before and after diagnosis are needed to confirm these findings. Public Library of Science 2020-03-25 /pmc/articles/PMC7094867/ /pubmed/32210471 http://dx.doi.org/10.1371/journal.pone.0229384 Text en © 2020 Evers et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Evers, Jelle Grotenhuis, Anne J. Aben, Katja K. H. Kiemeney, Lambertus A. L. M. Vrieling, Alina No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression |
title | No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression |
title_full | No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression |
title_fullStr | No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression |
title_full_unstemmed | No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression |
title_short | No clear associations of adult BMI and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression |
title_sort | no clear associations of adult bmi and diabetes mellitus with non-muscle invasive bladder cancer recurrence and progression |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094867/ https://www.ncbi.nlm.nih.gov/pubmed/32210471 http://dx.doi.org/10.1371/journal.pone.0229384 |
work_keys_str_mv | AT eversjelle noclearassociationsofadultbmianddiabetesmellituswithnonmuscleinvasivebladdercancerrecurrenceandprogression AT grotenhuisannej noclearassociationsofadultbmianddiabetesmellituswithnonmuscleinvasivebladdercancerrecurrenceandprogression AT abenkatjakh noclearassociationsofadultbmianddiabetesmellituswithnonmuscleinvasivebladdercancerrecurrenceandprogression AT kiemeneylambertusalm noclearassociationsofadultbmianddiabetesmellituswithnonmuscleinvasivebladdercancerrecurrenceandprogression AT vrielingalina noclearassociationsofadultbmianddiabetesmellituswithnonmuscleinvasivebladdercancerrecurrenceandprogression |