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4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound

Derivatives of flavan have been synthesized as chemical intermediates, but the only reported biological action is the ability of certain alkyl and alkoxy derivatives to lower blood cholesterol concentrations(1). It was therefore surprising to discover that flavan itself (Table 1) is a highly effecti...

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Detalles Bibliográficos
Autores principales: Bauer, D. J., Selway, J. W. T., Batchelor, J. F., Tisdale, Margaret, Caldwell, Ian C., Young, D. A. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 1981
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094996/
https://www.ncbi.nlm.nih.gov/pubmed/6265792
http://dx.doi.org/10.1038/292369a0
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author Bauer, D. J.
Selway, J. W. T.
Batchelor, J. F.
Tisdale, Margaret
Caldwell, Ian C.
Young, D. A. B.
author_facet Bauer, D. J.
Selway, J. W. T.
Batchelor, J. F.
Tisdale, Margaret
Caldwell, Ian C.
Young, D. A. B.
author_sort Bauer, D. J.
collection PubMed
description Derivatives of flavan have been synthesized as chemical intermediates, but the only reported biological action is the ability of certain alkyl and alkoxy derivatives to lower blood cholesterol concentrations(1). It was therefore surprising to discover that flavan itself (Table 1) is a highly effective inhibitor of the replication of certain serotypes of rhinovirus, and that a simple derivative, BW683C (4′,6-dichloroflavan), is the most potent antiviral compound yet reported. The present work examines the antiviral activity of flavan derivatives with a view to selecting the compound most suitable for trial in volunteers infected with a common cold virus.
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spelling pubmed-70949962020-03-26 4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound Bauer, D. J. Selway, J. W. T. Batchelor, J. F. Tisdale, Margaret Caldwell, Ian C. Young, D. A. B. Nature Article Derivatives of flavan have been synthesized as chemical intermediates, but the only reported biological action is the ability of certain alkyl and alkoxy derivatives to lower blood cholesterol concentrations(1). It was therefore surprising to discover that flavan itself (Table 1) is a highly effective inhibitor of the replication of certain serotypes of rhinovirus, and that a simple derivative, BW683C (4′,6-dichloroflavan), is the most potent antiviral compound yet reported. The present work examines the antiviral activity of flavan derivatives with a view to selecting the compound most suitable for trial in volunteers infected with a common cold virus. Nature Publishing Group UK 1981 /pmc/articles/PMC7094996/ /pubmed/6265792 http://dx.doi.org/10.1038/292369a0 Text en © Nature Publishing Group 1981 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Bauer, D. J.
Selway, J. W. T.
Batchelor, J. F.
Tisdale, Margaret
Caldwell, Ian C.
Young, D. A. B.
4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound
title 4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound
title_full 4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound
title_fullStr 4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound
title_full_unstemmed 4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound
title_short 4′,6-Dichloroflavan (BW683C), a new anti-rhinovirus compound
title_sort 4′,6-dichloroflavan (bw683c), a new anti-rhinovirus compound
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094996/
https://www.ncbi.nlm.nih.gov/pubmed/6265792
http://dx.doi.org/10.1038/292369a0
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