Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes

The repeated mini-exon sequence that encodes the first 35 base pairs of all variant surface antigen mRNAs of Trypanosoma brucei directs the synthesis of a discrete 137-nucleotide transcript. It thus seems that variant surface antigen mRNAs are transcribed discontinuously, and we present two alternat...

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Detalles Bibliográficos
Autores principales: Campbell, David A., Thornton, Deborah A., Boothroyd, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 1984
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095118/
https://www.ncbi.nlm.nih.gov/pubmed/6090933
http://dx.doi.org/10.1038/311350a0
Descripción
Sumario:The repeated mini-exon sequence that encodes the first 35 base pairs of all variant surface antigen mRNAs of Trypanosoma brucei directs the synthesis of a discrete 137-nucleotide transcript. It thus seems that variant surface antigen mRNAs are transcribed discontinuously, and we present two alternative models for how this might occur.

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