Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes

The repeated mini-exon sequence that encodes the first 35 base pairs of all variant surface antigen mRNAs of Trypanosoma brucei directs the synthesis of a discrete 137-nucleotide transcript. It thus seems that variant surface antigen mRNAs are transcribed discontinuously, and we present two alternat...

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Detalles Bibliográficos
Autores principales: Campbell, David A., Thornton, Deborah A., Boothroyd, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 1984
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095118/
https://www.ncbi.nlm.nih.gov/pubmed/6090933
http://dx.doi.org/10.1038/311350a0
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author Campbell, David A.
Thornton, Deborah A.
Boothroyd, John C.
author_facet Campbell, David A.
Thornton, Deborah A.
Boothroyd, John C.
author_sort Campbell, David A.
collection PubMed
description The repeated mini-exon sequence that encodes the first 35 base pairs of all variant surface antigen mRNAs of Trypanosoma brucei directs the synthesis of a discrete 137-nucleotide transcript. It thus seems that variant surface antigen mRNAs are transcribed discontinuously, and we present two alternative models for how this might occur.
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spelling pubmed-70951182020-03-26 Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes Campbell, David A. Thornton, Deborah A. Boothroyd, John C. Nature Article The repeated mini-exon sequence that encodes the first 35 base pairs of all variant surface antigen mRNAs of Trypanosoma brucei directs the synthesis of a discrete 137-nucleotide transcript. It thus seems that variant surface antigen mRNAs are transcribed discontinuously, and we present two alternative models for how this might occur. Nature Publishing Group UK 1984 /pmc/articles/PMC7095118/ /pubmed/6090933 http://dx.doi.org/10.1038/311350a0 Text en © Nature Publishing Group 1984 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Campbell, David A.
Thornton, Deborah A.
Boothroyd, John C.
Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes
title Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes
title_full Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes
title_fullStr Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes
title_full_unstemmed Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes
title_short Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes
title_sort apparent discontinuous transcription of trypanosoma brucei variant surface antigen genes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095118/
https://www.ncbi.nlm.nih.gov/pubmed/6090933
http://dx.doi.org/10.1038/311350a0
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