Liver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis B vaccine: a possible relationship?

We describe a patient in whom clinical evidence of liver and lung dysfunction developed after he received the second dose of recombinant hepatitis B vaccine, despite no serologic evidence of viral hepatitis. However, liver biopsy specimens demonstrated both surface antigens and core antigens, possib...

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Autores principales: Ranieri, V. M., Dell’Erba, A., Gentile, A., Bruno, F., Gioia, V. La, Spagnolo, A., Sacco, R., Caruso, G., Antonaci, S., Schiraldi, O., Brienza, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 1997
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095156/
https://www.ncbi.nlm.nih.gov/pubmed/9037652
http://dx.doi.org/10.1007/s001340050302
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author Ranieri, V. M.
Dell’Erba, A.
Gentile, A.
Bruno, F.
Gioia, V. La
Spagnolo, A.
Sacco, R.
Caruso, G.
Antonaci, S.
Schiraldi, O.
Brienza, A.
author_facet Ranieri, V. M.
Dell’Erba, A.
Gentile, A.
Bruno, F.
Gioia, V. La
Spagnolo, A.
Sacco, R.
Caruso, G.
Antonaci, S.
Schiraldi, O.
Brienza, A.
author_sort Ranieri, V. M.
collection PubMed
description We describe a patient in whom clinical evidence of liver and lung dysfunction developed after he received the second dose of recombinant hepatitis B vaccine, despite no serologic evidence of viral hepatitis. However, liver biopsy specimens demonstrated both surface antigens and core antigens, possibly indicating silent hepatitis B virus infection. A search for an infective etiology for the patient’s subsequent clinical deterioration in lung function did not yield pathogens; postmortem examination revealed evidence of immune complex-mediated organ injury in the liver, lungs, and kidneys.
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spelling pubmed-70951562020-03-26 Liver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis B vaccine: a possible relationship? Ranieri, V. M. Dell’Erba, A. Gentile, A. Bruno, F. Gioia, V. La Spagnolo, A. Sacco, R. Caruso, G. Antonaci, S. Schiraldi, O. Brienza, A. Intensive Care Med Brief Report We describe a patient in whom clinical evidence of liver and lung dysfunction developed after he received the second dose of recombinant hepatitis B vaccine, despite no serologic evidence of viral hepatitis. However, liver biopsy specimens demonstrated both surface antigens and core antigens, possibly indicating silent hepatitis B virus infection. A search for an infective etiology for the patient’s subsequent clinical deterioration in lung function did not yield pathogens; postmortem examination revealed evidence of immune complex-mediated organ injury in the liver, lungs, and kidneys. Springer-Verlag 1997 /pmc/articles/PMC7095156/ /pubmed/9037652 http://dx.doi.org/10.1007/s001340050302 Text en © Springer-Verlag Berlin Heidelberg 1997 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Ranieri, V. M.
Dell’Erba, A.
Gentile, A.
Bruno, F.
Gioia, V. La
Spagnolo, A.
Sacco, R.
Caruso, G.
Antonaci, S.
Schiraldi, O.
Brienza, A.
Liver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis B vaccine: a possible relationship?
title Liver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis B vaccine: a possible relationship?
title_full Liver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis B vaccine: a possible relationship?
title_fullStr Liver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis B vaccine: a possible relationship?
title_full_unstemmed Liver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis B vaccine: a possible relationship?
title_short Liver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis B vaccine: a possible relationship?
title_sort liver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis b vaccine: a possible relationship?
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095156/
https://www.ncbi.nlm.nih.gov/pubmed/9037652
http://dx.doi.org/10.1007/s001340050302
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