Mediators of multiple organ failure

Multiple Organ Failure (MOF) has largely been attributed to bacterial sepsis, though conclusive evidence of an essential role for bacteria and/or their endotoxins is still lacking. On the other hand, MOF and the clinical syndrome of sepsis may be aseptically induced in germfree animals. This paper r...

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Detalles Bibliográficos
Autor principal: Goris, R. J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095330/
https://www.ncbi.nlm.nih.gov/pubmed/2289989
http://dx.doi.org/10.1007/BF01709699
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author Goris, R. J. A.
author_facet Goris, R. J. A.
author_sort Goris, R. J. A.
collection PubMed
description Multiple Organ Failure (MOF) has largely been attributed to bacterial sepsis, though conclusive evidence of an essential role for bacteria and/or their endotoxins is still lacking. On the other hand, MOF and the clinical syndrome of sepsis may be aseptically induced in germfree animals. This paper reviews the evidence that excessive activation of endogenous humoral mediators and inflammatory cells may cause this highly lethal syndrome.
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spelling pubmed-70953302020-03-26 Mediators of multiple organ failure Goris, R. J. A. Intensive Care Med Article Multiple Organ Failure (MOF) has largely been attributed to bacterial sepsis, though conclusive evidence of an essential role for bacteria and/or their endotoxins is still lacking. On the other hand, MOF and the clinical syndrome of sepsis may be aseptically induced in germfree animals. This paper reviews the evidence that excessive activation of endogenous humoral mediators and inflammatory cells may cause this highly lethal syndrome. Springer-Verlag 1990 /pmc/articles/PMC7095330/ /pubmed/2289989 http://dx.doi.org/10.1007/BF01709699 Text en © Springer-Verlag 1990 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Goris, R. J. A.
Mediators of multiple organ failure
title Mediators of multiple organ failure
title_full Mediators of multiple organ failure
title_fullStr Mediators of multiple organ failure
title_full_unstemmed Mediators of multiple organ failure
title_short Mediators of multiple organ failure
title_sort mediators of multiple organ failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095330/
https://www.ncbi.nlm.nih.gov/pubmed/2289989
http://dx.doi.org/10.1007/BF01709699
work_keys_str_mv AT gorisrja mediatorsofmultipleorganfailure

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