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Koch's postulates fulfilled for SARS virus

Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease, resulting globally in 435 deaths from 6,234 probable cases (as of 3 May 2003). Here we provide proof from experimental infection of cynomolgus macaques (Macaca fascicularis) that the newly discovered SARS-associate...

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Autores principales: Fouchier, Ron A. M., Kuiken, Thijs, Schutten, Martin, van Amerongen, Geert, van Doornum, Gerard J. J., van den Hoogen, Bernadette G., Peiris, Malik, Lim, Wilina, Stöhr, Klaus, Osterhaus, Albert D. M. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095368/
https://www.ncbi.nlm.nih.gov/pubmed/12748632
http://dx.doi.org/10.1038/423240a
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author Fouchier, Ron A. M.
Kuiken, Thijs
Schutten, Martin
van Amerongen, Geert
van Doornum, Gerard J. J.
van den Hoogen, Bernadette G.
Peiris, Malik
Lim, Wilina
Stöhr, Klaus
Osterhaus, Albert D. M. E.
author_facet Fouchier, Ron A. M.
Kuiken, Thijs
Schutten, Martin
van Amerongen, Geert
van Doornum, Gerard J. J.
van den Hoogen, Bernadette G.
Peiris, Malik
Lim, Wilina
Stöhr, Klaus
Osterhaus, Albert D. M. E.
author_sort Fouchier, Ron A. M.
collection PubMed
description Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease, resulting globally in 435 deaths from 6,234 probable cases (as of 3 May 2003). Here we provide proof from experimental infection of cynomolgus macaques (Macaca fascicularis) that the newly discovered SARS-associated coronavirus (SCV) is the aetiological agent of this disease. Our understanding of the aetiology of SARS will expedite the development of diagnostic tests, antiviral therapies and vaccines, and may allow a more concise case definition for this emerging disease. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/423240a) contains supplementary material, which is available to authorized users.
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spelling pubmed-70953682020-03-26 Koch's postulates fulfilled for SARS virus Fouchier, Ron A. M. Kuiken, Thijs Schutten, Martin van Amerongen, Geert van Doornum, Gerard J. J. van den Hoogen, Bernadette G. Peiris, Malik Lim, Wilina Stöhr, Klaus Osterhaus, Albert D. M. E. Nature Article Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease, resulting globally in 435 deaths from 6,234 probable cases (as of 3 May 2003). Here we provide proof from experimental infection of cynomolgus macaques (Macaca fascicularis) that the newly discovered SARS-associated coronavirus (SCV) is the aetiological agent of this disease. Our understanding of the aetiology of SARS will expedite the development of diagnostic tests, antiviral therapies and vaccines, and may allow a more concise case definition for this emerging disease. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/423240a) contains supplementary material, which is available to authorized users. Nature Publishing Group UK 2003 /pmc/articles/PMC7095368/ /pubmed/12748632 http://dx.doi.org/10.1038/423240a Text en © Nature Publishing Group 2003 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Fouchier, Ron A. M.
Kuiken, Thijs
Schutten, Martin
van Amerongen, Geert
van Doornum, Gerard J. J.
van den Hoogen, Bernadette G.
Peiris, Malik
Lim, Wilina
Stöhr, Klaus
Osterhaus, Albert D. M. E.
Koch's postulates fulfilled for SARS virus
title Koch's postulates fulfilled for SARS virus
title_full Koch's postulates fulfilled for SARS virus
title_fullStr Koch's postulates fulfilled for SARS virus
title_full_unstemmed Koch's postulates fulfilled for SARS virus
title_short Koch's postulates fulfilled for SARS virus
title_sort koch's postulates fulfilled for sars virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095368/
https://www.ncbi.nlm.nih.gov/pubmed/12748632
http://dx.doi.org/10.1038/423240a
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