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Acute disseminated encephalomyelitis: current knowledge and open questions

Acute disseminated encephalomyelitis (ADEM) is usually an acute, multi-focal, and monophasic immune-mediated disease of the central nervous system. The disorder is mainly a condition of the pediatric age group, but neurologists are also involved in the management of adult patients. The lack of defin...

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Detalles Bibliográficos
Autores principales: Steiner, Israel, Kennedy, Peter G. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095407/
https://www.ncbi.nlm.nih.gov/pubmed/26037112
http://dx.doi.org/10.1007/s13365-015-0353-z
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author Steiner, Israel
Kennedy, Peter G. E.
author_facet Steiner, Israel
Kennedy, Peter G. E.
author_sort Steiner, Israel
collection PubMed
description Acute disseminated encephalomyelitis (ADEM) is usually an acute, multi-focal, and monophasic immune-mediated disease of the central nervous system. The disorder is mainly a condition of the pediatric age group, but neurologists are also involved in the management of adult patients. The lack of defined diagnostic criteria for ADEM underlies the limited understanding of its epidemiology, etiology, pathogenesis, course, prognosis, therapy, as well as the association with, and distinction from, multiple sclerosis. The present review summarizes current knowledge and outlines unanswered questions the answers to which should be eventually provided through a synergistic combination of clinical and basic research.
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spelling pubmed-70954072020-03-26 Acute disseminated encephalomyelitis: current knowledge and open questions Steiner, Israel Kennedy, Peter G. E. J Neurovirol Mini-Review Acute disseminated encephalomyelitis (ADEM) is usually an acute, multi-focal, and monophasic immune-mediated disease of the central nervous system. The disorder is mainly a condition of the pediatric age group, but neurologists are also involved in the management of adult patients. The lack of defined diagnostic criteria for ADEM underlies the limited understanding of its epidemiology, etiology, pathogenesis, course, prognosis, therapy, as well as the association with, and distinction from, multiple sclerosis. The present review summarizes current knowledge and outlines unanswered questions the answers to which should be eventually provided through a synergistic combination of clinical and basic research. Springer US 2015-06-03 2015 /pmc/articles/PMC7095407/ /pubmed/26037112 http://dx.doi.org/10.1007/s13365-015-0353-z Text en © Journal of NeuroVirology, Inc. 2015 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Mini-Review
Steiner, Israel
Kennedy, Peter G. E.
Acute disseminated encephalomyelitis: current knowledge and open questions
title Acute disseminated encephalomyelitis: current knowledge and open questions
title_full Acute disseminated encephalomyelitis: current knowledge and open questions
title_fullStr Acute disseminated encephalomyelitis: current knowledge and open questions
title_full_unstemmed Acute disseminated encephalomyelitis: current knowledge and open questions
title_short Acute disseminated encephalomyelitis: current knowledge and open questions
title_sort acute disseminated encephalomyelitis: current knowledge and open questions
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095407/
https://www.ncbi.nlm.nih.gov/pubmed/26037112
http://dx.doi.org/10.1007/s13365-015-0353-z
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