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A pneumonia outbreak associated with a new coronavirus of probable bat origin

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats(1–4). Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans(5–7). Here...

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Detalles Bibliográficos
Autores principales: Zhou, Peng, Yang, Xing-Lou, Wang, Xian-Guang, Hu, Ben, Zhang, Lei, Zhang, Wei, Si, Hao-Rui, Zhu, Yan, Li, Bei, Huang, Chao-Lin, Chen, Hui-Dong, Chen, Jing, Luo, Yun, Guo, Hua, Jiang, Ren-Di, Liu, Mei-Qin, Chen, Ying, Shen, Xu-Rui, Wang, Xi, Zheng, Xiao-Shuang, Zhao, Kai, Chen, Quan-Jiao, Deng, Fei, Liu, Lin-Lin, Yan, Bing, Zhan, Fa-Xian, Wang, Yan-Yi, Xiao, Geng-Fu, Shi, Zheng-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095418/
https://www.ncbi.nlm.nih.gov/pubmed/32015507
http://dx.doi.org/10.1038/s41586-020-2012-7
Descripción
Sumario:Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats(1–4). Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans(5–7). Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.