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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats(1–4). Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans(5–7). Here...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095418/ https://www.ncbi.nlm.nih.gov/pubmed/32015507 http://dx.doi.org/10.1038/s41586-020-2012-7 |
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author | Zhou, Peng Yang, Xing-Lou Wang, Xian-Guang Hu, Ben Zhang, Lei Zhang, Wei Si, Hao-Rui Zhu, Yan Li, Bei Huang, Chao-Lin Chen, Hui-Dong Chen, Jing Luo, Yun Guo, Hua Jiang, Ren-Di Liu, Mei-Qin Chen, Ying Shen, Xu-Rui Wang, Xi Zheng, Xiao-Shuang Zhao, Kai Chen, Quan-Jiao Deng, Fei Liu, Lin-Lin Yan, Bing Zhan, Fa-Xian Wang, Yan-Yi Xiao, Geng-Fu Shi, Zheng-Li |
author_facet | Zhou, Peng Yang, Xing-Lou Wang, Xian-Guang Hu, Ben Zhang, Lei Zhang, Wei Si, Hao-Rui Zhu, Yan Li, Bei Huang, Chao-Lin Chen, Hui-Dong Chen, Jing Luo, Yun Guo, Hua Jiang, Ren-Di Liu, Mei-Qin Chen, Ying Shen, Xu-Rui Wang, Xi Zheng, Xiao-Shuang Zhao, Kai Chen, Quan-Jiao Deng, Fei Liu, Lin-Lin Yan, Bing Zhan, Fa-Xian Wang, Yan-Yi Xiao, Geng-Fu Shi, Zheng-Li |
author_sort | Zhou, Peng |
collection | PubMed |
description | Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats(1–4). Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans(5–7). Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV. |
format | Online Article Text |
id | pubmed-7095418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70954182020-03-26 A pneumonia outbreak associated with a new coronavirus of probable bat origin Zhou, Peng Yang, Xing-Lou Wang, Xian-Guang Hu, Ben Zhang, Lei Zhang, Wei Si, Hao-Rui Zhu, Yan Li, Bei Huang, Chao-Lin Chen, Hui-Dong Chen, Jing Luo, Yun Guo, Hua Jiang, Ren-Di Liu, Mei-Qin Chen, Ying Shen, Xu-Rui Wang, Xi Zheng, Xiao-Shuang Zhao, Kai Chen, Quan-Jiao Deng, Fei Liu, Lin-Lin Yan, Bing Zhan, Fa-Xian Wang, Yan-Yi Xiao, Geng-Fu Shi, Zheng-Li Nature Article Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats(1–4). Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans(5–7). Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV. Nature Publishing Group UK 2020-02-03 2020 /pmc/articles/PMC7095418/ /pubmed/32015507 http://dx.doi.org/10.1038/s41586-020-2012-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhou, Peng Yang, Xing-Lou Wang, Xian-Guang Hu, Ben Zhang, Lei Zhang, Wei Si, Hao-Rui Zhu, Yan Li, Bei Huang, Chao-Lin Chen, Hui-Dong Chen, Jing Luo, Yun Guo, Hua Jiang, Ren-Di Liu, Mei-Qin Chen, Ying Shen, Xu-Rui Wang, Xi Zheng, Xiao-Shuang Zhao, Kai Chen, Quan-Jiao Deng, Fei Liu, Lin-Lin Yan, Bing Zhan, Fa-Xian Wang, Yan-Yi Xiao, Geng-Fu Shi, Zheng-Li A pneumonia outbreak associated with a new coronavirus of probable bat origin |
title | A pneumonia outbreak associated with a new coronavirus of probable bat origin |
title_full | A pneumonia outbreak associated with a new coronavirus of probable bat origin |
title_fullStr | A pneumonia outbreak associated with a new coronavirus of probable bat origin |
title_full_unstemmed | A pneumonia outbreak associated with a new coronavirus of probable bat origin |
title_short | A pneumonia outbreak associated with a new coronavirus of probable bat origin |
title_sort | pneumonia outbreak associated with a new coronavirus of probable bat origin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095418/ https://www.ncbi.nlm.nih.gov/pubmed/32015507 http://dx.doi.org/10.1038/s41586-020-2012-7 |
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