Gentransfer mit adenoviralen Vektoren

Adenoviral vectors are promising vectors for somatic gene therapy in a number of inherited and acquired disorders. In this contribution, the current scientific knowledge as it relates to production and function of adenoviral vectors is summarized. The different types of adenoviral vectors are descri...

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Detalles Bibliográficos
Autor principal: Kochanek, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2001
Materias:
Leitthema: Gentherapie: Forschung, Entwicklung und Regularien
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095895/
http://dx.doi.org/10.1007/s00103-001-0292-0
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author Kochanek, S.
author_facet Kochanek, S.
author_sort Kochanek, S.
collection PubMed
description Adenoviral vectors are promising vectors for somatic gene therapy in a number of inherited and acquired disorders. In this contribution, the current scientific knowledge as it relates to production and function of adenoviral vectors is summarized. The different types of adenoviral vectors are described and their respective advantages and disadvantages are delineated. Current problems with adenoviral vectors, and implications as they derive from the fatality observed in the Philadelphia gene therapy trial are discussed.
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spelling pubmed-70958952020-03-26 Gentransfer mit adenoviralen Vektoren Kochanek, S. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Leitthema: Gentherapie: Forschung, Entwicklung und Regularien Adenoviral vectors are promising vectors for somatic gene therapy in a number of inherited and acquired disorders. In this contribution, the current scientific knowledge as it relates to production and function of adenoviral vectors is summarized. The different types of adenoviral vectors are described and their respective advantages and disadvantages are delineated. Current problems with adenoviral vectors, and implications as they derive from the fatality observed in the Philadelphia gene therapy trial are discussed. Springer-Verlag 2001 /pmc/articles/PMC7095895/ http://dx.doi.org/10.1007/s00103-001-0292-0 Text en © Springer-Verlag Berlin Heidelberg 2001 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Leitthema: Gentherapie: Forschung, Entwicklung und Regularien
Kochanek, S.
Gentransfer mit adenoviralen Vektoren
title Gentransfer mit adenoviralen Vektoren
title_full Gentransfer mit adenoviralen Vektoren
title_fullStr Gentransfer mit adenoviralen Vektoren
title_full_unstemmed Gentransfer mit adenoviralen Vektoren
title_short Gentransfer mit adenoviralen Vektoren
title_sort gentransfer mit adenoviralen vektoren
topic Leitthema: Gentherapie: Forschung, Entwicklung und Regularien
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095895/
http://dx.doi.org/10.1007/s00103-001-0292-0
work_keys_str_mv AT kochaneks gentransfermitadenoviralenvektoren

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