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Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen
The expected cost explosion in transfusion medicine increases the socio-economic significance of specific institutional transfusion programs. In this context the estimated use of the patient’s physiologic tolerance represents an integral part of any blood conservation concept. The present article su...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095997/ https://www.ncbi.nlm.nih.gov/pubmed/17429601 http://dx.doi.org/10.1007/s00120-007-1344-3 |
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author | Habler, O. Meier, J. Pape, A. Kertscho, H. Zwißler, B. |
author_facet | Habler, O. Meier, J. Pape, A. Kertscho, H. Zwißler, B. |
author_sort | Habler, O. |
collection | PubMed |
description | The expected cost explosion in transfusion medicine increases the socio-economic significance of specific institutional transfusion programs. In this context the estimated use of the patient’s physiologic tolerance represents an integral part of any blood conservation concept. The present article summarizes the mechanisms, influencing factors and limits of this natural tolerance to anemia and deduces the indication for perioperative red blood cell transfusion. The current recommendations coincide to the effect that perioperative transfusion is unnecessary up to a Hb concentration of 10 g/dl (6.21 mmol/l) even in older patients with cardiopulmonary comorbidity and is only recommended in cases of Hb <6 g/dl (<3.72 mmol/l) in otherwise healthy subjects including pregnant women and children. Critically ill patients with multiple trauma and sepsis do not seem to benefit from transfusions up to Hb concentrations >9 g/dl (>5.59 mmol/l). In cases of massive hemorrhaging and diffuse bleeding disorders the maintenance of a Hb concentration of 10 g/dl (6.21 mmol/l) seems to contribute to stabilization of coagulation. |
format | Online Article Text |
id | pubmed-7095997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-70959972020-03-26 Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen Habler, O. Meier, J. Pape, A. Kertscho, H. Zwißler, B. Urologe A CME Weiterbildung • Zertifizierte Fortbildung The expected cost explosion in transfusion medicine increases the socio-economic significance of specific institutional transfusion programs. In this context the estimated use of the patient’s physiologic tolerance represents an integral part of any blood conservation concept. The present article summarizes the mechanisms, influencing factors and limits of this natural tolerance to anemia and deduces the indication for perioperative red blood cell transfusion. The current recommendations coincide to the effect that perioperative transfusion is unnecessary up to a Hb concentration of 10 g/dl (6.21 mmol/l) even in older patients with cardiopulmonary comorbidity and is only recommended in cases of Hb <6 g/dl (<3.72 mmol/l) in otherwise healthy subjects including pregnant women and children. Critically ill patients with multiple trauma and sepsis do not seem to benefit from transfusions up to Hb concentrations >9 g/dl (>5.59 mmol/l). In cases of massive hemorrhaging and diffuse bleeding disorders the maintenance of a Hb concentration of 10 g/dl (6.21 mmol/l) seems to contribute to stabilization of coagulation. Springer-Verlag 2007-05-08 2007 /pmc/articles/PMC7095997/ /pubmed/17429601 http://dx.doi.org/10.1007/s00120-007-1344-3 Text en © Springer Medizin Verlag 2007 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | CME Weiterbildung • Zertifizierte Fortbildung Habler, O. Meier, J. Pape, A. Kertscho, H. Zwißler, B. Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen |
title | Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen |
title_full | Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen |
title_fullStr | Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen |
title_full_unstemmed | Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen |
title_short | Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen |
title_sort | perioperative anämietoleranz: mechanismen, einflussfaktoren, grenzen |
topic | CME Weiterbildung • Zertifizierte Fortbildung |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095997/ https://www.ncbi.nlm.nih.gov/pubmed/17429601 http://dx.doi.org/10.1007/s00120-007-1344-3 |
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