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Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen

The expected cost explosion in transfusion medicine increases the socio-economic significance of specific institutional transfusion programs. In this context the estimated use of the patient’s physiologic tolerance represents an integral part of any blood conservation concept. The present article su...

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Autores principales: Habler, O., Meier, J., Pape, A., Kertscho, H., Zwißler, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095997/
https://www.ncbi.nlm.nih.gov/pubmed/17429601
http://dx.doi.org/10.1007/s00120-007-1344-3
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author Habler, O.
Meier, J.
Pape, A.
Kertscho, H.
Zwißler, B.
author_facet Habler, O.
Meier, J.
Pape, A.
Kertscho, H.
Zwißler, B.
author_sort Habler, O.
collection PubMed
description The expected cost explosion in transfusion medicine increases the socio-economic significance of specific institutional transfusion programs. In this context the estimated use of the patient’s physiologic tolerance represents an integral part of any blood conservation concept. The present article summarizes the mechanisms, influencing factors and limits of this natural tolerance to anemia and deduces the indication for perioperative red blood cell transfusion. The current recommendations coincide to the effect that perioperative transfusion is unnecessary up to a Hb concentration of 10 g/dl (6.21 mmol/l) even in older patients with cardiopulmonary comorbidity and is only recommended in cases of Hb <6 g/dl (<3.72 mmol/l) in otherwise healthy subjects including pregnant women and children. Critically ill patients with multiple trauma and sepsis do not seem to benefit from transfusions up to Hb concentrations >9 g/dl (>5.59 mmol/l). In cases of massive hemorrhaging and diffuse bleeding disorders the maintenance of a Hb concentration of 10 g/dl (6.21 mmol/l) seems to contribute to stabilization of coagulation.
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spelling pubmed-70959972020-03-26 Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen Habler, O. Meier, J. Pape, A. Kertscho, H. Zwißler, B. Urologe A CME Weiterbildung • Zertifizierte Fortbildung The expected cost explosion in transfusion medicine increases the socio-economic significance of specific institutional transfusion programs. In this context the estimated use of the patient’s physiologic tolerance represents an integral part of any blood conservation concept. The present article summarizes the mechanisms, influencing factors and limits of this natural tolerance to anemia and deduces the indication for perioperative red blood cell transfusion. The current recommendations coincide to the effect that perioperative transfusion is unnecessary up to a Hb concentration of 10 g/dl (6.21 mmol/l) even in older patients with cardiopulmonary comorbidity and is only recommended in cases of Hb <6 g/dl (<3.72 mmol/l) in otherwise healthy subjects including pregnant women and children. Critically ill patients with multiple trauma and sepsis do not seem to benefit from transfusions up to Hb concentrations >9 g/dl (>5.59 mmol/l). In cases of massive hemorrhaging and diffuse bleeding disorders the maintenance of a Hb concentration of 10 g/dl (6.21 mmol/l) seems to contribute to stabilization of coagulation. Springer-Verlag 2007-05-08 2007 /pmc/articles/PMC7095997/ /pubmed/17429601 http://dx.doi.org/10.1007/s00120-007-1344-3 Text en © Springer Medizin Verlag 2007 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle CME Weiterbildung • Zertifizierte Fortbildung
Habler, O.
Meier, J.
Pape, A.
Kertscho, H.
Zwißler, B.
Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen
title Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen
title_full Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen
title_fullStr Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen
title_full_unstemmed Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen
title_short Perioperative Anämietoleranz: Mechanismen, Einflussfaktoren, Grenzen
title_sort perioperative anämietoleranz: mechanismen, einflussfaktoren, grenzen
topic CME Weiterbildung • Zertifizierte Fortbildung
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095997/
https://www.ncbi.nlm.nih.gov/pubmed/17429601
http://dx.doi.org/10.1007/s00120-007-1344-3
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