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From Pasteur to genomics: progress and challenges in infectious diseases

Over the past decade, microbiology and infectious disease research have undergone the most profound revolution since the times of Pasteur. Genomic sequencing has revealed the much-awaited blueprint of most pathogens. Screening blood for the nucleic acids of infectious agents has blunted the spread o...

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Autor principal: Rappuoli, Rino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096024/
https://www.ncbi.nlm.nih.gov/pubmed/15516917
http://dx.doi.org/10.1038/nm1129
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author Rappuoli, Rino
author_facet Rappuoli, Rino
author_sort Rappuoli, Rino
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description Over the past decade, microbiology and infectious disease research have undergone the most profound revolution since the times of Pasteur. Genomic sequencing has revealed the much-awaited blueprint of most pathogens. Screening blood for the nucleic acids of infectious agents has blunted the spread of pathogens by transfusion, the field of antiviral therapeutics has exploded and technologies for the development of novel and safer vaccines have become available. The quantum jump in our ability to detect, prevent and treat infectious diseases resulting from improved technologies and genomics was moderated during this period by the greatest emergence of new infectious agents ever recorded and a worrisome increase in resistance to existing therapies. Dozens of new infectious diseases are expected to emerge in the coming decades. Controlling these diseases will require a better understanding of the worldwide threat and economic burden of infectious diseases and a global agenda.
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spelling pubmed-70960242020-03-26 From Pasteur to genomics: progress and challenges in infectious diseases Rappuoli, Rino Nat Med Article Over the past decade, microbiology and infectious disease research have undergone the most profound revolution since the times of Pasteur. Genomic sequencing has revealed the much-awaited blueprint of most pathogens. Screening blood for the nucleic acids of infectious agents has blunted the spread of pathogens by transfusion, the field of antiviral therapeutics has exploded and technologies for the development of novel and safer vaccines have become available. The quantum jump in our ability to detect, prevent and treat infectious diseases resulting from improved technologies and genomics was moderated during this period by the greatest emergence of new infectious agents ever recorded and a worrisome increase in resistance to existing therapies. Dozens of new infectious diseases are expected to emerge in the coming decades. Controlling these diseases will require a better understanding of the worldwide threat and economic burden of infectious diseases and a global agenda. Nature Publishing Group US 2004-10-29 2004 /pmc/articles/PMC7096024/ /pubmed/15516917 http://dx.doi.org/10.1038/nm1129 Text en © Nature Publishing Group 2004 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Rappuoli, Rino
From Pasteur to genomics: progress and challenges in infectious diseases
title From Pasteur to genomics: progress and challenges in infectious diseases
title_full From Pasteur to genomics: progress and challenges in infectious diseases
title_fullStr From Pasteur to genomics: progress and challenges in infectious diseases
title_full_unstemmed From Pasteur to genomics: progress and challenges in infectious diseases
title_short From Pasteur to genomics: progress and challenges in infectious diseases
title_sort from pasteur to genomics: progress and challenges in infectious diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096024/
https://www.ncbi.nlm.nih.gov/pubmed/15516917
http://dx.doi.org/10.1038/nm1129
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