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Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer
BACKGROUND/AIMS: Patients treated with endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) are at risk of developing metachronous gastric cancer (MGC). The aim of this study was to evaluate the clinical outcomes of MGC after ESD for EGC between the re-ESD and surgery groups. METHOD...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editorial Office of Gut and Liver
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096239/ https://www.ncbi.nlm.nih.gov/pubmed/31158949 http://dx.doi.org/10.5009/gnl18575 |
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author | Kim, Jue Lie Kim, Sang Gyun Kim, Jung Park, Jae Yong Yang, Hyo-Joon Kim, Hyun Ju Chung, Hyunsoo |
author_facet | Kim, Jue Lie Kim, Sang Gyun Kim, Jung Park, Jae Yong Yang, Hyo-Joon Kim, Hyun Ju Chung, Hyunsoo |
author_sort | Kim, Jue Lie |
collection | PubMed |
description | BACKGROUND/AIMS: Patients treated with endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) are at risk of developing metachronous gastric cancer (MGC). The aim of this study was to evaluate the clinical outcomes of MGC after ESD for EGC between the re-ESD and surgery groups. METHODS: In total, data from 1,510 patients who underwent ESD for EGC from January 2005 to May 2014 were retrospectively reviewed, and data from 112 patients with MGC were analyzed according to the type of treatment, namely, re-ESD and surgery. The clinicopathological factors affecting the subsequent treatment and outcomes of MGC were evaluated. RESULTS: The median duration to the development of MGC was 47 months. In multivariate analysis, lower body mass index (BMI) (p=0.037) and multiplicity (p=0.014) of index cases were significantly associated with subsequent surgery for MGC. In cases of MGC, a diffuse or mixed-type Lauren classification (p=0.009), the depth of tumor mucosal invasion (p=0.001), and an upper stomach location (p=0.049) were associated with surgery. Overall survival was significantly shorter in the surgery group than in the re-ESD group after treatment for MGC (log-rank test, p=0.01). CONCLUSIONS: Lower BMI and multiplicity of index cancers were significantly associated with the surgical resection of MGC. Close follow-up is needed to minimize additional treatment for cases at high risk of advanced MGC after ESD for EGC. |
format | Online Article Text |
id | pubmed-7096239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Editorial Office of Gut and Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-70962392020-04-02 Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer Kim, Jue Lie Kim, Sang Gyun Kim, Jung Park, Jae Yong Yang, Hyo-Joon Kim, Hyun Ju Chung, Hyunsoo Gut Liver Original Article BACKGROUND/AIMS: Patients treated with endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) are at risk of developing metachronous gastric cancer (MGC). The aim of this study was to evaluate the clinical outcomes of MGC after ESD for EGC between the re-ESD and surgery groups. METHODS: In total, data from 1,510 patients who underwent ESD for EGC from January 2005 to May 2014 were retrospectively reviewed, and data from 112 patients with MGC were analyzed according to the type of treatment, namely, re-ESD and surgery. The clinicopathological factors affecting the subsequent treatment and outcomes of MGC were evaluated. RESULTS: The median duration to the development of MGC was 47 months. In multivariate analysis, lower body mass index (BMI) (p=0.037) and multiplicity (p=0.014) of index cases were significantly associated with subsequent surgery for MGC. In cases of MGC, a diffuse or mixed-type Lauren classification (p=0.009), the depth of tumor mucosal invasion (p=0.001), and an upper stomach location (p=0.049) were associated with surgery. Overall survival was significantly shorter in the surgery group than in the re-ESD group after treatment for MGC (log-rank test, p=0.01). CONCLUSIONS: Lower BMI and multiplicity of index cancers were significantly associated with the surgical resection of MGC. Close follow-up is needed to minimize additional treatment for cases at high risk of advanced MGC after ESD for EGC. Editorial Office of Gut and Liver 2020-03-15 2019-11-11 /pmc/articles/PMC7096239/ /pubmed/31158949 http://dx.doi.org/10.5009/gnl18575 Text en Copyright © 2020 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Jue Lie Kim, Sang Gyun Kim, Jung Park, Jae Yong Yang, Hyo-Joon Kim, Hyun Ju Chung, Hyunsoo Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer |
title | Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer |
title_full | Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer |
title_fullStr | Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer |
title_full_unstemmed | Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer |
title_short | Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer |
title_sort | clinical outcomes of metachronous gastric cancer after endoscopic resection for early gastric cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096239/ https://www.ncbi.nlm.nih.gov/pubmed/31158949 http://dx.doi.org/10.5009/gnl18575 |
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