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Regional brain volumes in brief psychotic disorder

Brief psychotic disorder (BPD) is a relatively rare representative of psychotic disorders. Structural brain abnormalities in BPD are not known. We compared 30 patients with BPD and 30 matched healthy controls using high-resolution structural T1-weighted magnetic resonance imaging (MRI). We performed...

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Autores principales: Li, Hua, Kéri, Szabolcs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096370/
https://www.ncbi.nlm.nih.gov/pubmed/31955300
http://dx.doi.org/10.1007/s00702-020-02140-y
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author Li, Hua
Kéri, Szabolcs
author_facet Li, Hua
Kéri, Szabolcs
author_sort Li, Hua
collection PubMed
description Brief psychotic disorder (BPD) is a relatively rare representative of psychotic disorders. Structural brain abnormalities in BPD are not known. We compared 30 patients with BPD and 30 matched healthy controls using high-resolution structural T1-weighted magnetic resonance imaging (MRI). We performed cortical/subcortical reconstruction and volumetric segmentation using FreeSurfer v6.0. Results revealed that the caudal/rostral middle frontal cortex, superior frontal cortex, and the frontal pole were significantly smaller in patients with BPD compared to controls. The number of lifetime psychotic episodes negatively correlated with caudal middle frontal and frontal pole volumes. These results indicate structural abnormalities of the frontal cortex in BPD, which are associated with the number of psychotic relapses.
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spelling pubmed-70963702020-03-27 Regional brain volumes in brief psychotic disorder Li, Hua Kéri, Szabolcs J Neural Transm (Vienna) Psychiatry and Preclinical Psychiatric Studies - Original Article Brief psychotic disorder (BPD) is a relatively rare representative of psychotic disorders. Structural brain abnormalities in BPD are not known. We compared 30 patients with BPD and 30 matched healthy controls using high-resolution structural T1-weighted magnetic resonance imaging (MRI). We performed cortical/subcortical reconstruction and volumetric segmentation using FreeSurfer v6.0. Results revealed that the caudal/rostral middle frontal cortex, superior frontal cortex, and the frontal pole were significantly smaller in patients with BPD compared to controls. The number of lifetime psychotic episodes negatively correlated with caudal middle frontal and frontal pole volumes. These results indicate structural abnormalities of the frontal cortex in BPD, which are associated with the number of psychotic relapses. Springer Vienna 2020-01-18 2020 /pmc/articles/PMC7096370/ /pubmed/31955300 http://dx.doi.org/10.1007/s00702-020-02140-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Psychiatry and Preclinical Psychiatric Studies - Original Article
Li, Hua
Kéri, Szabolcs
Regional brain volumes in brief psychotic disorder
title Regional brain volumes in brief psychotic disorder
title_full Regional brain volumes in brief psychotic disorder
title_fullStr Regional brain volumes in brief psychotic disorder
title_full_unstemmed Regional brain volumes in brief psychotic disorder
title_short Regional brain volumes in brief psychotic disorder
title_sort regional brain volumes in brief psychotic disorder
topic Psychiatry and Preclinical Psychiatric Studies - Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096370/
https://www.ncbi.nlm.nih.gov/pubmed/31955300
http://dx.doi.org/10.1007/s00702-020-02140-y
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