Cargando…
Pressure Overload Is Associated With Low Levels of Troponin I and Myosin Binding Protein C Phosphorylation in the Hearts of Patients With Aortic Stenosis
In previous studies of septal heart muscle from HCM patients with hypertrophic obstructive cardiomyopathy (HOCM, LVOT gradient 50–120 mmHg) we found that the level of phosphorylation of troponin I (TnI) and myosin binding protein C (MyBP-C) was extremely low yet samples from hearts with HCM or DCM m...
Autores principales: | Copeland, O’neal, Messer, Andrew, Jabbour, Andrew, Poggesi, Corrado, Prasad, Sanjay, Marston, Steven |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096377/ https://www.ncbi.nlm.nih.gov/pubmed/32265736 http://dx.doi.org/10.3389/fphys.2020.00241 |
Ejemplares similares
-
Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy
por: Messer, Andrew E., et al.
Publicado: (2014) -
Investigations into the Sarcomeric Protein and Ca(2+)-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus)
por: Messer, Andrew E., et al.
Publicado: (2017) -
The Dilated Cardiomyopathy-Causing Mutation ACTC E361G in Cardiac Muscle Myofibrils Specifically Abolishes Modulation of Ca(2+) Regulation by Phosphorylation of Troponin I
por: Vikhorev, Petr G., et al.
Publicado: (2014) -
The Importance of Intrinsically Disordered Segments of Cardiac Troponin in Modulating Function by Phosphorylation and Disease-Causing Mutations
por: Papadaki, Maria, et al.
Publicado: (2016) -
Molecular Defects in Cardiac Myofilament Ca(2+)-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin
por: Sheehan, Alice, et al.
Publicado: (2018)