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Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A

Neolignan licarin A (1) was isolated from leaves of Nectandra oppositifolia (Lauraceae) and displayed activity against trypomastigote forms of the etiologic agent of American trypanosomiasis, Trypanosoma cruzi. Aiming for the establishment of SAR, five different compounds (1a – 1e) were prepared and...

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Detalles Bibliográficos
Autores principales:	Morais, Thiago R., Conserva, Geanne A. Alves, Varela, Marina T., Costa-Silva, Thais A., Thevenard, Fernanda, Ponci, Vitor, Fortuna, Ana, Falcão, Amílcar C., Tempone, Andre G., Fernandes, João Paulo S., Lago, João Henrique G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096397/ https://www.ncbi.nlm.nih.gov/pubmed/32214193 http://dx.doi.org/10.1038/s41598-020-62352-w

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