CDK1 dependent phosphorylation of hTERT contributes to cancer progression

The telomerase reverse transcriptase is upregulated in the majority of human cancers and contributes directly to cell transformation. Here we report that hTERT is phosphorylated at threonine 249 during mitosis by the serine/threonine kinase CDK1. Clinicopathological analyses reveal that phosphorylat...

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Detalles Bibliográficos
Autores principales: Yasukawa, Mami, Ando, Yoshinari, Yamashita, Taro, Matsuda, Yoko, Shoji, Shisako, Morioka, Masaki Suimye, Kawaji, Hideya, Shiozawa, Kumiko, Machitani, Mitsuhiro, Abe, Takaya, Yamada, Shinji, Kaneko, Mika K., Kato, Yukinari, Furuta, Yasuhide, Kondo, Tadashi, Shirouzu, Mikako, Hayashizaki, Yoshihide, Kaneko, Shuichi, Masutomi, Kenkichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096428/
https://www.ncbi.nlm.nih.gov/pubmed/32214089
http://dx.doi.org/10.1038/s41467-020-15289-7

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