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Metastasis-associated fibroblasts promote angiogenesis in metastasized pancreatic cancer via the CXCL8 and the CCL2 axes

The characteristic desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a key contributor to its lethality. This stromal microenvironment is populated by cancer-associated fibroblasts (CAFs) that interact with cancer cells to drive progression and chemo-resistance. Research has focused...

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Detalles Bibliográficos
Autores principales:	Pausch, Thomas M., Aue, Elisa, Wirsik, Naita M., Freire Valls, Aida, Shen, Ying, Radhakrishnan, Praveen, Hackert, Thilo, Schneider, Martin, Schmidt, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096431/ https://www.ncbi.nlm.nih.gov/pubmed/32214219 http://dx.doi.org/10.1038/s41598-020-62416-x

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