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Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets

Today, we face difficulty in generating new hypotheses and understanding oral lichen planus due to the large amount of biomedical information available. In this research, we have used an integrated bioinformatics approach assimilating information from data mining, gene ontologies, protein–protein in...

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Autores principales: Rivera, César, Crisóstomo, Mariangela Fernanda, Peña, Carolina, González-Díaz, Paulina, González-Arriagada, Wilfredo Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096434/
https://www.ncbi.nlm.nih.gov/pubmed/32214134
http://dx.doi.org/10.1038/s41598-020-62258-7
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author Rivera, César
Crisóstomo, Mariangela Fernanda
Peña, Carolina
González-Díaz, Paulina
González-Arriagada, Wilfredo Alejandro
author_facet Rivera, César
Crisóstomo, Mariangela Fernanda
Peña, Carolina
González-Díaz, Paulina
González-Arriagada, Wilfredo Alejandro
author_sort Rivera, César
collection PubMed
description Today, we face difficulty in generating new hypotheses and understanding oral lichen planus due to the large amount of biomedical information available. In this research, we have used an integrated bioinformatics approach assimilating information from data mining, gene ontologies, protein–protein interaction and network analysis to predict candidate genes related to oral lichen planus. A detailed pathway analysis led us to propose two promising therapeutic targets: the stromal cell derived factor 1 (CXCL12) and the C-X-C type 4 chemokine receptor (CXCR4). We further validated our predictions and found that CXCR4 was upregulated in all oral lichen planus tissue samples. Our bioinformatics data cumulatively support the pathological role of chemokines and chemokine receptors in oral lichen planus. From a clinical perspective, we suggest a drug (plerixafor) and two therapeutic targets for future research.
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spelling pubmed-70964342020-03-30 Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets Rivera, César Crisóstomo, Mariangela Fernanda Peña, Carolina González-Díaz, Paulina González-Arriagada, Wilfredo Alejandro Sci Rep Article Today, we face difficulty in generating new hypotheses and understanding oral lichen planus due to the large amount of biomedical information available. In this research, we have used an integrated bioinformatics approach assimilating information from data mining, gene ontologies, protein–protein interaction and network analysis to predict candidate genes related to oral lichen planus. A detailed pathway analysis led us to propose two promising therapeutic targets: the stromal cell derived factor 1 (CXCL12) and the C-X-C type 4 chemokine receptor (CXCR4). We further validated our predictions and found that CXCR4 was upregulated in all oral lichen planus tissue samples. Our bioinformatics data cumulatively support the pathological role of chemokines and chemokine receptors in oral lichen planus. From a clinical perspective, we suggest a drug (plerixafor) and two therapeutic targets for future research. Nature Publishing Group UK 2020-03-25 /pmc/articles/PMC7096434/ /pubmed/32214134 http://dx.doi.org/10.1038/s41598-020-62258-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Rivera, César
Crisóstomo, Mariangela Fernanda
Peña, Carolina
González-Díaz, Paulina
González-Arriagada, Wilfredo Alejandro
Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets
title Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets
title_full Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets
title_fullStr Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets
title_full_unstemmed Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets
title_short Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets
title_sort oral lichen planus interactome reveals cxcr4 and cxcl12 as candidate therapeutic targets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096434/
https://www.ncbi.nlm.nih.gov/pubmed/32214134
http://dx.doi.org/10.1038/s41598-020-62258-7
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