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Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability

Genomic destabilisation is associated with the induction of mutations, including those in cancer-driver genes, and subsequent clonal evolution of cells with abrogated defence systems. Such mutations are not induced when genome stability is maintained; however, the mechanisms involved in genome stabi...

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Autores principales: Matsuno, Yusuke, Atsumi, Yuko, Alauddin, Md., Rana, Md. Masud, Fujimori, Haruka, Hyodo, Mai, Shimizu, Atsuhiro, Ikuta, Tomoki, Tani, Hiroko, Torigoe, Hidetaka, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Komai, Michio, Shirakawa, Hitoshi, Yoshioka, Ken-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096489/
https://www.ncbi.nlm.nih.gov/pubmed/32214146
http://dx.doi.org/10.1038/s41598-020-62292-5
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author Matsuno, Yusuke
Atsumi, Yuko
Alauddin, Md.
Rana, Md. Masud
Fujimori, Haruka
Hyodo, Mai
Shimizu, Atsuhiro
Ikuta, Tomoki
Tani, Hiroko
Torigoe, Hidetaka
Nakatsu, Yoshimichi
Tsuzuki, Teruhisa
Komai, Michio
Shirakawa, Hitoshi
Yoshioka, Ken-ichi
author_facet Matsuno, Yusuke
Atsumi, Yuko
Alauddin, Md.
Rana, Md. Masud
Fujimori, Haruka
Hyodo, Mai
Shimizu, Atsuhiro
Ikuta, Tomoki
Tani, Hiroko
Torigoe, Hidetaka
Nakatsu, Yoshimichi
Tsuzuki, Teruhisa
Komai, Michio
Shirakawa, Hitoshi
Yoshioka, Ken-ichi
author_sort Matsuno, Yusuke
collection PubMed
description Genomic destabilisation is associated with the induction of mutations, including those in cancer-driver genes, and subsequent clonal evolution of cells with abrogated defence systems. Such mutations are not induced when genome stability is maintained; however, the mechanisms involved in genome stability maintenance remain elusive. Here, resveratrol (and related polyphenols) is shown to enhance genome stability in mouse embryonic fibroblasts, ultimately protecting the cells against the induction of mutations in the ARF/p53 pathway. Replication stress-associated DNA double-strand breaks (DSBs) that accumulated with genomic destabilisation were effectively reduced by resveratrol treatment. In addition, resveratrol transiently stabilised the expression of histone H2AX, which is involved in DSB repair. Similar effects on the maintenance of genome stability were observed for related polyphenols. Accordingly, we propose that polyphenol consumption can contribute to the suppression of cancers that develop with genomic instability, as well as lifespan extension.
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spelling pubmed-70964892020-03-30 Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability Matsuno, Yusuke Atsumi, Yuko Alauddin, Md. Rana, Md. Masud Fujimori, Haruka Hyodo, Mai Shimizu, Atsuhiro Ikuta, Tomoki Tani, Hiroko Torigoe, Hidetaka Nakatsu, Yoshimichi Tsuzuki, Teruhisa Komai, Michio Shirakawa, Hitoshi Yoshioka, Ken-ichi Sci Rep Article Genomic destabilisation is associated with the induction of mutations, including those in cancer-driver genes, and subsequent clonal evolution of cells with abrogated defence systems. Such mutations are not induced when genome stability is maintained; however, the mechanisms involved in genome stability maintenance remain elusive. Here, resveratrol (and related polyphenols) is shown to enhance genome stability in mouse embryonic fibroblasts, ultimately protecting the cells against the induction of mutations in the ARF/p53 pathway. Replication stress-associated DNA double-strand breaks (DSBs) that accumulated with genomic destabilisation were effectively reduced by resveratrol treatment. In addition, resveratrol transiently stabilised the expression of histone H2AX, which is involved in DSB repair. Similar effects on the maintenance of genome stability were observed for related polyphenols. Accordingly, we propose that polyphenol consumption can contribute to the suppression of cancers that develop with genomic instability, as well as lifespan extension. Nature Publishing Group UK 2020-03-25 /pmc/articles/PMC7096489/ /pubmed/32214146 http://dx.doi.org/10.1038/s41598-020-62292-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Matsuno, Yusuke
Atsumi, Yuko
Alauddin, Md.
Rana, Md. Masud
Fujimori, Haruka
Hyodo, Mai
Shimizu, Atsuhiro
Ikuta, Tomoki
Tani, Hiroko
Torigoe, Hidetaka
Nakatsu, Yoshimichi
Tsuzuki, Teruhisa
Komai, Michio
Shirakawa, Hitoshi
Yoshioka, Ken-ichi
Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability
title Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability
title_full Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability
title_fullStr Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability
title_full_unstemmed Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability
title_short Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability
title_sort resveratrol and its related polyphenols contribute to the maintenance of genome stability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096489/
https://www.ncbi.nlm.nih.gov/pubmed/32214146
http://dx.doi.org/10.1038/s41598-020-62292-5
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