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The First 3D Model of the Full-Length KIT Cytoplasmic Domain Reveals a New Look for an Old Receptor

Receptor tyrosine kinases (RTKs) are key regulators of normal cellular processes and have a critical role in the development and progression of many diseases. RTK ligand-induced stimulation leads to activation of the cytoplasmic kinase domain that controls the intracellular signalling. Although the...

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Detalles Bibliográficos
Autores principales:	Inizan, François, Hanna, Myriam, Stolyarchuk, Maxim, Chauvot de Beauchêne, Isaure, Tchertanov, Luba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096506/ https://www.ncbi.nlm.nih.gov/pubmed/32214210 http://dx.doi.org/10.1038/s41598-020-62460-7

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