Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat

Staphylococcus aureus lipase (SAL), a triacylglycerol esterase, is an important virulence factor and may be a therapeutic target for infectious diseases. Herein, we determined the 3D structure of native SAL, the mutated S116A inactive form, and the inhibitor complex using the anti-obesity drug orlis...

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Detalles Bibliográficos
Autores principales: Kitadokoro, Kengo, Tanaka, Mutsumi, Hikima, Takaaki, Okuno, Yukiko, Yamamoto, Masaki, Kamitani, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096528/
https://www.ncbi.nlm.nih.gov/pubmed/32214208
http://dx.doi.org/10.1038/s41598-020-62427-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096528/
https://www.ncbi.nlm.nih.gov/pubmed/32214208
http://dx.doi.org/10.1038/s41598-020-62427-8

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