A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

c-MET receptors are activated in cancers through genomic events like tyrosine kinase domain mutations, juxtamembrane splicing mutation and amplified copy numbers, which can be inhibited by c-MET small molecule inhibitors. Here, we discover that the most common polymorphism known to affect MET gene (...

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Detalles Bibliográficos
Autores principales: Kong, Li Ren, Mohamed Salleh, Nur Afiqah Binte, Ong, Richard Weijie, Tan, Tuan Zea, Syn, Nicholas L., Goh, Robby Miguel, Fhu, Chee Wai, Tan, Daniel S. W., Iyer, N. Gopalakrishna, Kannan, Srinivasaraghavan, Verma, Chandra S., Lim, Yaw Chyn, Soo, Ross, Ho, Jingshan, Huang, Yiqing, Lim, Joline S. J., Yan, Benedict Junrong, Nga, Min En, Lim, Seng Gee, Koeffler, H. Phillip, Lee, Soo Chin, Kappei, Dennis, Hung, Huynh The, Goh, Boon Cher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096530/
https://www.ncbi.nlm.nih.gov/pubmed/32214092
http://dx.doi.org/10.1038/s41467-020-15318-5

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