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Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein–protein interactions

BRG1/SMARCA4 and its paralog BRM/SMARCA2 are the ATPase subunits of human SWI/SNF chromatin remodeling complexes. These multisubunit assemblies can act as either tumor suppressors or drivers of cancer, and inhibiting both BRG1 and BRM, is emerging as an effective therapeutic strategy in diverse canc...

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Detalles Bibliográficos
Autores principales:	Allen, Mark D., Bycroft, Mark, Zinzalla, Giovanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Protein Structure Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096718/ https://www.ncbi.nlm.nih.gov/pubmed/31909846 http://dx.doi.org/10.1002/pro.3820

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