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CD28-Dependent CTLA-4 Expression Fine-Tunes the Activation of Human Th17 Cells

Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells. We found that selective CD28 blockade with a domain antib...

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Detalles Bibliográficos
Autores principales:	Krummey, Scott M., Hartigan, Christina R., Liu, Danya, Ford, Mandy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096747/ https://www.ncbi.nlm.nih.gov/pubmed/32203908 http://dx.doi.org/10.1016/j.isci.2020.100912

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