Concepts in Boolean network modeling: What do they all mean?

Boolean network models are one of the simplest models to study complex dynamic behavior in biological systems. They can be applied to unravel the mechanisms regulating the properties of the system or to identify promising intervention targets. Since its introduction by Stuart Kauffman in 1969 for de...

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Detalles Bibliográficos
Autores principales: Schwab, Julian D., Kühlwein, Silke D., Ikonomi, Nensi, Kühl, Michael, Kestler, Hans A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096748/
https://www.ncbi.nlm.nih.gov/pubmed/32257043
http://dx.doi.org/10.1016/j.csbj.2020.03.001
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author Schwab, Julian D.
Kühlwein, Silke D.
Ikonomi, Nensi
Kühl, Michael
Kestler, Hans A.
author_facet Schwab, Julian D.
Kühlwein, Silke D.
Ikonomi, Nensi
Kühl, Michael
Kestler, Hans A.
author_sort Schwab, Julian D.
collection PubMed
description Boolean network models are one of the simplest models to study complex dynamic behavior in biological systems. They can be applied to unravel the mechanisms regulating the properties of the system or to identify promising intervention targets. Since its introduction by Stuart Kauffman in 1969 for describing gene regulatory networks, various biologically based networks and tools for their analysis were developed. Here, we summarize and explain the concepts for Boolean network modeling. We also present application examples and guidelines to work with and analyze Boolean network models.
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spelling pubmed-70967482020-03-31 Concepts in Boolean network modeling: What do they all mean? Schwab, Julian D. Kühlwein, Silke D. Ikonomi, Nensi Kühl, Michael Kestler, Hans A. Comput Struct Biotechnol J Review Article Boolean network models are one of the simplest models to study complex dynamic behavior in biological systems. They can be applied to unravel the mechanisms regulating the properties of the system or to identify promising intervention targets. Since its introduction by Stuart Kauffman in 1969 for describing gene regulatory networks, various biologically based networks and tools for their analysis were developed. Here, we summarize and explain the concepts for Boolean network modeling. We also present application examples and guidelines to work with and analyze Boolean network models. Research Network of Computational and Structural Biotechnology 2020-03-10 /pmc/articles/PMC7096748/ /pubmed/32257043 http://dx.doi.org/10.1016/j.csbj.2020.03.001 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Schwab, Julian D.
Kühlwein, Silke D.
Ikonomi, Nensi
Kühl, Michael
Kestler, Hans A.
Concepts in Boolean network modeling: What do they all mean?
title Concepts in Boolean network modeling: What do they all mean?
title_full Concepts in Boolean network modeling: What do they all mean?
title_fullStr Concepts in Boolean network modeling: What do they all mean?
title_full_unstemmed Concepts in Boolean network modeling: What do they all mean?
title_short Concepts in Boolean network modeling: What do they all mean?
title_sort concepts in boolean network modeling: what do they all mean?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096748/
https://www.ncbi.nlm.nih.gov/pubmed/32257043
http://dx.doi.org/10.1016/j.csbj.2020.03.001
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