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A non-proliferative role of pyrimidine metabolism in cancer

BACKGROUND: Nucleotide metabolism is a critical pathway that generates purine and pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics. Increased nucleotide metabolism supports uncontrolled growth of tumors and is a hallmark of cancer. Agents inhibiting synthesis and i...

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Detalles Bibliográficos
Autores principales:	Siddiqui, Aarif, Ceppi, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096759/ https://www.ncbi.nlm.nih.gov/pubmed/32244187 http://dx.doi.org/10.1016/j.molmet.2020.02.005

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