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Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels

Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on th...

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Detalles Bibliográficos
Autores principales: Kadri, R., Bacharouch, J., Elkhoury, K., Ben Messaoud, G., Kahn, C., Desobry, S., Linder, M., Tamayol, A., Francius, G., Mano, J.F., Sánchez-González, L., Arab-Tehrany, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096761/
https://www.ncbi.nlm.nih.gov/pubmed/32259100
http://dx.doi.org/10.1016/j.mtbio.2020.100046
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author Kadri, R.
Bacharouch, J.
Elkhoury, K.
Ben Messaoud, G.
Kahn, C.
Desobry, S.
Linder, M.
Tamayol, A.
Francius, G.
Mano, J.F.
Sánchez-González, L.
Arab-Tehrany, E.
author_facet Kadri, R.
Bacharouch, J.
Elkhoury, K.
Ben Messaoud, G.
Kahn, C.
Desobry, S.
Linder, M.
Tamayol, A.
Francius, G.
Mano, J.F.
Sánchez-González, L.
Arab-Tehrany, E.
author_sort Kadri, R.
collection PubMed
description Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte ​growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering.
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spelling pubmed-70967612020-03-31 Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels Kadri, R. Bacharouch, J. Elkhoury, K. Ben Messaoud, G. Kahn, C. Desobry, S. Linder, M. Tamayol, A. Francius, G. Mano, J.F. Sánchez-González, L. Arab-Tehrany, E. Mater Today Bio Full Length Article Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte ​growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering. Elsevier 2020-02-27 /pmc/articles/PMC7096761/ /pubmed/32259100 http://dx.doi.org/10.1016/j.mtbio.2020.100046 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Full Length Article
Kadri, R.
Bacharouch, J.
Elkhoury, K.
Ben Messaoud, G.
Kahn, C.
Desobry, S.
Linder, M.
Tamayol, A.
Francius, G.
Mano, J.F.
Sánchez-González, L.
Arab-Tehrany, E.
Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels
title Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels
title_full Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels
title_fullStr Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels
title_full_unstemmed Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels
title_short Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels
title_sort role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096761/
https://www.ncbi.nlm.nih.gov/pubmed/32259100
http://dx.doi.org/10.1016/j.mtbio.2020.100046
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