Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3–23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a s...

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Detalles Bibliográficos
Autores principales: Haveri, Anu, Smura, Teemu, Kuivanen, Suvi, Österlund, Pamela, Hepojoki, Jussi, Ikonen, Niina, Pitkäpaasi, Marjaana, Blomqvist, Soile, Rönkkö, Esa, Kantele, Anu, Strandin, Tomas, Kallio-Kokko, Hannimari, Mannonen, Laura, Lappalainen, Maija, Broas, Markku, Jiang, Miao, Siira, Lotta, Salminen, Mika, Puumalainen, Taneli, Sane, Jussi, Melin, Merit, Vapalahti, Olli, Savolainen-Kopra, Carita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096774/
https://www.ncbi.nlm.nih.gov/pubmed/32209163
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.11.2000266
Descripción
Sumario:The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3–23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.

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