SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly

SRSF7 is an essential RNA-binding protein whose misexpression promotes cancer. Here, we describe how SRSF7 maintains its protein homeostasis in murine P19 cells using an intricate negative feedback mechanism. SRSF7 binding to its premessenger RNA promotes inclusion of a poison cassette exon and tran...

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Detalles Bibliográficos
Autores principales: Königs, Vanessa, de Oliveira Freitas Machado, Camila, Arnold, Benjamin, Blümel, Nicole, Solovyeva, Anfisa, Löbbert, Sinah, Schafranek, Michal, Ruiz De Los Mozos, Igor, Wittig, Ilka, McNicoll, Francois, Schulz, Marcel H., Müller-McNicoll, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096898/
https://www.ncbi.nlm.nih.gov/pubmed/32123389
http://dx.doi.org/10.1038/s41594-020-0385-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096898/
https://www.ncbi.nlm.nih.gov/pubmed/32123389
http://dx.doi.org/10.1038/s41594-020-0385-9

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