The population genetics and evolutionary epidemiology of RNA viruses

RNA viruses are ubiquitous intracellular parasites that are responsible for many emerging diseases, including AIDS and SARS. Here, we discuss the principal mechanisms of RNA virus evolution and highlight areas where future research is required. The rapidity of sequence change in RNA viruses means th...

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Autores principales: Moya, Andrés, Holmes, Edward C., González-Candelas, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096949/
https://www.ncbi.nlm.nih.gov/pubmed/15031727
http://dx.doi.org/10.1038/nrmicro863
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author Moya, Andrés
Holmes, Edward C.
González-Candelas, Fernando
author_facet Moya, Andrés
Holmes, Edward C.
González-Candelas, Fernando
author_sort Moya, Andrés
collection PubMed
description RNA viruses are ubiquitous intracellular parasites that are responsible for many emerging diseases, including AIDS and SARS. Here, we discuss the principal mechanisms of RNA virus evolution and highlight areas where future research is required. The rapidity of sequence change in RNA viruses means that they are useful experimental models for the study of evolution in general and it enables us to watch them change in 'real time', and retrace the spread through populations with molecular phylogenies. An understanding of the mechanisms of RNA virus sequence change is also crucial to predicting important aspects of their emergence and long-term evolution.
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spelling pubmed-70969492020-03-26 The population genetics and evolutionary epidemiology of RNA viruses Moya, Andrés Holmes, Edward C. González-Candelas, Fernando Nat Rev Microbiol Article RNA viruses are ubiquitous intracellular parasites that are responsible for many emerging diseases, including AIDS and SARS. Here, we discuss the principal mechanisms of RNA virus evolution and highlight areas where future research is required. The rapidity of sequence change in RNA viruses means that they are useful experimental models for the study of evolution in general and it enables us to watch them change in 'real time', and retrace the spread through populations with molecular phylogenies. An understanding of the mechanisms of RNA virus sequence change is also crucial to predicting important aspects of their emergence and long-term evolution. Nature Publishing Group UK 2004 /pmc/articles/PMC7096949/ /pubmed/15031727 http://dx.doi.org/10.1038/nrmicro863 Text en © Nature Publishing Group 2004 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Moya, Andrés
Holmes, Edward C.
González-Candelas, Fernando
The population genetics and evolutionary epidemiology of RNA viruses
title The population genetics and evolutionary epidemiology of RNA viruses
title_full The population genetics and evolutionary epidemiology of RNA viruses
title_fullStr The population genetics and evolutionary epidemiology of RNA viruses
title_full_unstemmed The population genetics and evolutionary epidemiology of RNA viruses
title_short The population genetics and evolutionary epidemiology of RNA viruses
title_sort population genetics and evolutionary epidemiology of rna viruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096949/
https://www.ncbi.nlm.nih.gov/pubmed/15031727
http://dx.doi.org/10.1038/nrmicro863
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