Molecular mechanisms of translational control

Translational control is widely used to regulate gene expression. This mode of regulation is especially relevant in situations where transcription is silent or when local control over protein accumulation is required. Although many examples of translational regulation have been described, only a few...

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Detalles Bibliográficos
Autores principales: Gebauer, Fátima, Hentze, Matthias W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097087/
https://www.ncbi.nlm.nih.gov/pubmed/15459663
http://dx.doi.org/10.1038/nrm1488
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author Gebauer, Fátima
Hentze, Matthias W.
author_facet Gebauer, Fátima
Hentze, Matthias W.
author_sort Gebauer, Fátima
collection PubMed
description Translational control is widely used to regulate gene expression. This mode of regulation is especially relevant in situations where transcription is silent or when local control over protein accumulation is required. Although many examples of translational regulation have been described, only a few are beginning to be mechanistically understood. Instead of providing a comprehensive account of the examples that are known at present, we discuss instructive cases that serve as paradigms for different modes of translational control.
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spelling pubmed-70970872020-03-26 Molecular mechanisms of translational control Gebauer, Fátima Hentze, Matthias W. Nat Rev Mol Cell Biol Article Translational control is widely used to regulate gene expression. This mode of regulation is especially relevant in situations where transcription is silent or when local control over protein accumulation is required. Although many examples of translational regulation have been described, only a few are beginning to be mechanistically understood. Instead of providing a comprehensive account of the examples that are known at present, we discuss instructive cases that serve as paradigms for different modes of translational control. Nature Publishing Group UK 2004 /pmc/articles/PMC7097087/ /pubmed/15459663 http://dx.doi.org/10.1038/nrm1488 Text en © Nature Publishing Group 2004 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Gebauer, Fátima
Hentze, Matthias W.
Molecular mechanisms of translational control
title Molecular mechanisms of translational control
title_full Molecular mechanisms of translational control
title_fullStr Molecular mechanisms of translational control
title_full_unstemmed Molecular mechanisms of translational control
title_short Molecular mechanisms of translational control
title_sort molecular mechanisms of translational control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097087/
https://www.ncbi.nlm.nih.gov/pubmed/15459663
http://dx.doi.org/10.1038/nrm1488
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