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Viral apoptotic mimicry

As opportunistic pathogens, viruses have evolved many elegant strategies to manipulate host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the exposure of phosphatidylserine — a marker for apoptosis — on the pathogen surface, is emerging as a common theme used by env...

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Detalles Bibliográficos
Autores principales: Amara, Ali, Mercer, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097103/
https://www.ncbi.nlm.nih.gov/pubmed/26052667
http://dx.doi.org/10.1038/nrmicro3469
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author Amara, Ali
Mercer, Jason
author_facet Amara, Ali
Mercer, Jason
author_sort Amara, Ali
collection PubMed
description As opportunistic pathogens, viruses have evolved many elegant strategies to manipulate host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the exposure of phosphatidylserine — a marker for apoptosis — on the pathogen surface, is emerging as a common theme used by enveloped viruses to promote infection. Focusing on the four best described examples (vaccinia virus, dengue virus, Ebola virus and pseudotyped lentivirus), we summarize our current understanding of apoptotic mimicry as a mechanism for virus entry, binding and immune evasion. We also describe recent examples of non-enveloped viruses that use this mimicry strategy, and discuss future directions and how viral apoptotic mimicry could be targeted therapeutically. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nrmicro3469) contains supplementary material, which is available to authorized users.
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spelling pubmed-70971032020-03-26 Viral apoptotic mimicry Amara, Ali Mercer, Jason Nat Rev Microbiol Article As opportunistic pathogens, viruses have evolved many elegant strategies to manipulate host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the exposure of phosphatidylserine — a marker for apoptosis — on the pathogen surface, is emerging as a common theme used by enveloped viruses to promote infection. Focusing on the four best described examples (vaccinia virus, dengue virus, Ebola virus and pseudotyped lentivirus), we summarize our current understanding of apoptotic mimicry as a mechanism for virus entry, binding and immune evasion. We also describe recent examples of non-enveloped viruses that use this mimicry strategy, and discuss future directions and how viral apoptotic mimicry could be targeted therapeutically. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nrmicro3469) contains supplementary material, which is available to authorized users. Nature Publishing Group UK 2015-06-08 2015 /pmc/articles/PMC7097103/ /pubmed/26052667 http://dx.doi.org/10.1038/nrmicro3469 Text en © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2015 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Amara, Ali
Mercer, Jason
Viral apoptotic mimicry
title Viral apoptotic mimicry
title_full Viral apoptotic mimicry
title_fullStr Viral apoptotic mimicry
title_full_unstemmed Viral apoptotic mimicry
title_short Viral apoptotic mimicry
title_sort viral apoptotic mimicry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097103/
https://www.ncbi.nlm.nih.gov/pubmed/26052667
http://dx.doi.org/10.1038/nrmicro3469
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