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Antiviral B cell and T cell immunity in the lungs

Respiratory viruses are frequent causes of repeated common colds, bronchitis and pneumonia, which often occur unpredictably as epidemics and pandemics. Despite those decimating effects on health and decades of intensive research, treatments remain largely supportive. The only commonly available vacc...

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Detalles Bibliográficos
Autores principales: Chiu, Christopher, Openshaw, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097128/
https://www.ncbi.nlm.nih.gov/pubmed/25521681
http://dx.doi.org/10.1038/ni.3056
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author Chiu, Christopher
Openshaw, Peter J
author_facet Chiu, Christopher
Openshaw, Peter J
author_sort Chiu, Christopher
collection PubMed
description Respiratory viruses are frequent causes of repeated common colds, bronchitis and pneumonia, which often occur unpredictably as epidemics and pandemics. Despite those decimating effects on health and decades of intensive research, treatments remain largely supportive. The only commonly available vaccines are against influenza virus, and even these need improvement. The lung shares some features with other mucosal sites, but preservation of its especially delicate anatomical structures necessitates a fine balance of pro- and anti-inflammatory responses; well-timed, appropriately placed and tightly regulated T cell and B cell responses are essential for protection from infection and limitation of symptoms, whereas poorly regulated inflammation contributes to tissue damage and disease. Recent advances in understanding adaptive immunity should facilitate vaccine development and reduce the global effect of respiratory viruses.
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spelling pubmed-70971282020-03-26 Antiviral B cell and T cell immunity in the lungs Chiu, Christopher Openshaw, Peter J Nat Immunol Article Respiratory viruses are frequent causes of repeated common colds, bronchitis and pneumonia, which often occur unpredictably as epidemics and pandemics. Despite those decimating effects on health and decades of intensive research, treatments remain largely supportive. The only commonly available vaccines are against influenza virus, and even these need improvement. The lung shares some features with other mucosal sites, but preservation of its especially delicate anatomical structures necessitates a fine balance of pro- and anti-inflammatory responses; well-timed, appropriately placed and tightly regulated T cell and B cell responses are essential for protection from infection and limitation of symptoms, whereas poorly regulated inflammation contributes to tissue damage and disease. Recent advances in understanding adaptive immunity should facilitate vaccine development and reduce the global effect of respiratory viruses. Nature Publishing Group US 2014-12-18 2015 /pmc/articles/PMC7097128/ /pubmed/25521681 http://dx.doi.org/10.1038/ni.3056 Text en © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2015 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Chiu, Christopher
Openshaw, Peter J
Antiviral B cell and T cell immunity in the lungs
title Antiviral B cell and T cell immunity in the lungs
title_full Antiviral B cell and T cell immunity in the lungs
title_fullStr Antiviral B cell and T cell immunity in the lungs
title_full_unstemmed Antiviral B cell and T cell immunity in the lungs
title_short Antiviral B cell and T cell immunity in the lungs
title_sort antiviral b cell and t cell immunity in the lungs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097128/
https://www.ncbi.nlm.nih.gov/pubmed/25521681
http://dx.doi.org/10.1038/ni.3056
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