Visualization of macromolecular structures

Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary m...

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Detalles Bibliográficos
Autores principales: O'Donoghue, Seán I, Goodsell, David S, Frangakis, Achilleas S, Jossinet, Fabrice, Laskowski, Roman A, Nilges, Michael, Saibil, Helen R, Schafferhans, Andrea, Wade, Rebecca C, Westhof, Eric, Olson, Arthur J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097155/
https://www.ncbi.nlm.nih.gov/pubmed/20195256
http://dx.doi.org/10.1038/nmeth.1427
Descripción
Sumario:Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nmeth.1427) contains supplementary material, which is available to authorized users.

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