Visualization of macromolecular structures

Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary m...

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Autores principales: O'Donoghue, Seán I, Goodsell, David S, Frangakis, Achilleas S, Jossinet, Fabrice, Laskowski, Roman A, Nilges, Michael, Saibil, Helen R, Schafferhans, Andrea, Wade, Rebecca C, Westhof, Eric, Olson, Arthur J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097155/
https://www.ncbi.nlm.nih.gov/pubmed/20195256
http://dx.doi.org/10.1038/nmeth.1427
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author O'Donoghue, Seán I
Goodsell, David S
Frangakis, Achilleas S
Jossinet, Fabrice
Laskowski, Roman A
Nilges, Michael
Saibil, Helen R
Schafferhans, Andrea
Wade, Rebecca C
Westhof, Eric
Olson, Arthur J
author_facet O'Donoghue, Seán I
Goodsell, David S
Frangakis, Achilleas S
Jossinet, Fabrice
Laskowski, Roman A
Nilges, Michael
Saibil, Helen R
Schafferhans, Andrea
Wade, Rebecca C
Westhof, Eric
Olson, Arthur J
author_sort O'Donoghue, Seán I
collection PubMed
description Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nmeth.1427) contains supplementary material, which is available to authorized users.
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spelling pubmed-70971552020-03-26 Visualization of macromolecular structures O'Donoghue, Seán I Goodsell, David S Frangakis, Achilleas S Jossinet, Fabrice Laskowski, Roman A Nilges, Michael Saibil, Helen R Schafferhans, Andrea Wade, Rebecca C Westhof, Eric Olson, Arthur J Nat Methods Article Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nmeth.1427) contains supplementary material, which is available to authorized users. Nature Publishing Group US 2010-03-01 2010 /pmc/articles/PMC7097155/ /pubmed/20195256 http://dx.doi.org/10.1038/nmeth.1427 Text en © Nature Publishing Group 2010 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
O'Donoghue, Seán I
Goodsell, David S
Frangakis, Achilleas S
Jossinet, Fabrice
Laskowski, Roman A
Nilges, Michael
Saibil, Helen R
Schafferhans, Andrea
Wade, Rebecca C
Westhof, Eric
Olson, Arthur J
Visualization of macromolecular structures
title Visualization of macromolecular structures
title_full Visualization of macromolecular structures
title_fullStr Visualization of macromolecular structures
title_full_unstemmed Visualization of macromolecular structures
title_short Visualization of macromolecular structures
title_sort visualization of macromolecular structures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097155/
https://www.ncbi.nlm.nih.gov/pubmed/20195256
http://dx.doi.org/10.1038/nmeth.1427
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