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Tissue-specific immunopathology during malaria infection
Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach all host tissues via the circulation. However, actual interactions between parasitized erythrocytes and host tissues, al...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097228/ https://www.ncbi.nlm.nih.gov/pubmed/29332936 http://dx.doi.org/10.1038/nri.2017.138 |
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author | Coban, Cevayir Lee, Michelle Sue Jann Ishii, Ken J. |
author_facet | Coban, Cevayir Lee, Michelle Sue Jann Ishii, Ken J. |
author_sort | Coban, Cevayir |
collection | PubMed |
description | Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach all host tissues via the circulation. However, actual interactions between parasitized erythrocytes and host tissues, along with the consequent damage and pathological changes, are limited locally to specific tissue sites. Such tissue specificity of the parasite can alter the outcome of malaria disease, determining whether acute or chronic complications occur. Here, we give an overview of the recent progress that has been made in understanding tissue-specific immunopathology during Plasmodium infection. As knowledge on tissue-specific host–parasite interactions accumulates, better treatment modalities and targets may emerge for intervention in malaria disease. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nri.2017.138) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7097228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70972282020-03-26 Tissue-specific immunopathology during malaria infection Coban, Cevayir Lee, Michelle Sue Jann Ishii, Ken J. Nat Rev Immunol Article Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach all host tissues via the circulation. However, actual interactions between parasitized erythrocytes and host tissues, along with the consequent damage and pathological changes, are limited locally to specific tissue sites. Such tissue specificity of the parasite can alter the outcome of malaria disease, determining whether acute or chronic complications occur. Here, we give an overview of the recent progress that has been made in understanding tissue-specific immunopathology during Plasmodium infection. As knowledge on tissue-specific host–parasite interactions accumulates, better treatment modalities and targets may emerge for intervention in malaria disease. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nri.2017.138) contains supplementary material, which is available to authorized users. Nature Publishing Group UK 2018-01-15 2018 /pmc/articles/PMC7097228/ /pubmed/29332936 http://dx.doi.org/10.1038/nri.2017.138 Text en © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2018 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Coban, Cevayir Lee, Michelle Sue Jann Ishii, Ken J. Tissue-specific immunopathology during malaria infection |
title | Tissue-specific immunopathology during malaria infection |
title_full | Tissue-specific immunopathology during malaria infection |
title_fullStr | Tissue-specific immunopathology during malaria infection |
title_full_unstemmed | Tissue-specific immunopathology during malaria infection |
title_short | Tissue-specific immunopathology during malaria infection |
title_sort | tissue-specific immunopathology during malaria infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097228/ https://www.ncbi.nlm.nih.gov/pubmed/29332936 http://dx.doi.org/10.1038/nri.2017.138 |
work_keys_str_mv | AT cobancevayir tissuespecificimmunopathologyduringmalariainfection AT leemichellesuejann tissuespecificimmunopathologyduringmalariainfection AT ishiikenj tissuespecificimmunopathologyduringmalariainfection |