Cargando…

Tissue-specific immunopathology during malaria infection

Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach all host tissues via the circulation. However, actual interactions between parasitized erythrocytes and host tissues, al...

Descripción completa

Detalles Bibliográficos
Autores principales: Coban, Cevayir, Lee, Michelle Sue Jann, Ishii, Ken J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097228/
https://www.ncbi.nlm.nih.gov/pubmed/29332936
http://dx.doi.org/10.1038/nri.2017.138
_version_ 1783510972990750720
author Coban, Cevayir
Lee, Michelle Sue Jann
Ishii, Ken J.
author_facet Coban, Cevayir
Lee, Michelle Sue Jann
Ishii, Ken J.
author_sort Coban, Cevayir
collection PubMed
description Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach all host tissues via the circulation. However, actual interactions between parasitized erythrocytes and host tissues, along with the consequent damage and pathological changes, are limited locally to specific tissue sites. Such tissue specificity of the parasite can alter the outcome of malaria disease, determining whether acute or chronic complications occur. Here, we give an overview of the recent progress that has been made in understanding tissue-specific immunopathology during Plasmodium infection. As knowledge on tissue-specific host–parasite interactions accumulates, better treatment modalities and targets may emerge for intervention in malaria disease. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nri.2017.138) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-7097228
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-70972282020-03-26 Tissue-specific immunopathology during malaria infection Coban, Cevayir Lee, Michelle Sue Jann Ishii, Ken J. Nat Rev Immunol Article Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach all host tissues via the circulation. However, actual interactions between parasitized erythrocytes and host tissues, along with the consequent damage and pathological changes, are limited locally to specific tissue sites. Such tissue specificity of the parasite can alter the outcome of malaria disease, determining whether acute or chronic complications occur. Here, we give an overview of the recent progress that has been made in understanding tissue-specific immunopathology during Plasmodium infection. As knowledge on tissue-specific host–parasite interactions accumulates, better treatment modalities and targets may emerge for intervention in malaria disease. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nri.2017.138) contains supplementary material, which is available to authorized users. Nature Publishing Group UK 2018-01-15 2018 /pmc/articles/PMC7097228/ /pubmed/29332936 http://dx.doi.org/10.1038/nri.2017.138 Text en © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2018 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Coban, Cevayir
Lee, Michelle Sue Jann
Ishii, Ken J.
Tissue-specific immunopathology during malaria infection
title Tissue-specific immunopathology during malaria infection
title_full Tissue-specific immunopathology during malaria infection
title_fullStr Tissue-specific immunopathology during malaria infection
title_full_unstemmed Tissue-specific immunopathology during malaria infection
title_short Tissue-specific immunopathology during malaria infection
title_sort tissue-specific immunopathology during malaria infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097228/
https://www.ncbi.nlm.nih.gov/pubmed/29332936
http://dx.doi.org/10.1038/nri.2017.138
work_keys_str_mv AT cobancevayir tissuespecificimmunopathologyduringmalariainfection
AT leemichellesuejann tissuespecificimmunopathologyduringmalariainfection
AT ishiikenj tissuespecificimmunopathologyduringmalariainfection