NALT- versus PEYER'S-patch-mediated mucosal immunity

Recent studies indicate that the mechanism of nasopharynx-associated lymphoid tissue (NALT) organogenesis is different from that of other lymphoid tissues. NALT has an important role in the induction of mucosal immune responses, including the generation of T helper 1 and T helper 2 cells, and IgA-co...

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Detalles Bibliográficos
Autores principales: Kiyono, Hiroshi, Fukuyama, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097243/
https://www.ncbi.nlm.nih.gov/pubmed/15343369
http://dx.doi.org/10.1038/nri1439
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author Kiyono, Hiroshi
Fukuyama, Satoshi
author_facet Kiyono, Hiroshi
Fukuyama, Satoshi
author_sort Kiyono, Hiroshi
collection PubMed
description Recent studies indicate that the mechanism of nasopharynx-associated lymphoid tissue (NALT) organogenesis is different from that of other lymphoid tissues. NALT has an important role in the induction of mucosal immune responses, including the generation of T helper 1 and T helper 2 cells, and IgA-committed B cells. Moreover, intranasal immunization can lead to the induction of antigen-specific protective immunity in both the mucosal and systemic immune compartments. Therefore, a greater understanding of the differences between NALT and other organized lymphoid tissues, such as Peyer's patches, should facilitate the development of nasal vaccines.
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spelling pubmed-70972432020-03-26 NALT- versus PEYER'S-patch-mediated mucosal immunity Kiyono, Hiroshi Fukuyama, Satoshi Nat Rev Immunol Article Recent studies indicate that the mechanism of nasopharynx-associated lymphoid tissue (NALT) organogenesis is different from that of other lymphoid tissues. NALT has an important role in the induction of mucosal immune responses, including the generation of T helper 1 and T helper 2 cells, and IgA-committed B cells. Moreover, intranasal immunization can lead to the induction of antigen-specific protective immunity in both the mucosal and systemic immune compartments. Therefore, a greater understanding of the differences between NALT and other organized lymphoid tissues, such as Peyer's patches, should facilitate the development of nasal vaccines. Nature Publishing Group UK 2004 /pmc/articles/PMC7097243/ /pubmed/15343369 http://dx.doi.org/10.1038/nri1439 Text en © Nature Publishing Group 2004 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Kiyono, Hiroshi
Fukuyama, Satoshi
NALT- versus PEYER'S-patch-mediated mucosal immunity
title NALT- versus PEYER'S-patch-mediated mucosal immunity
title_full NALT- versus PEYER'S-patch-mediated mucosal immunity
title_fullStr NALT- versus PEYER'S-patch-mediated mucosal immunity
title_full_unstemmed NALT- versus PEYER'S-patch-mediated mucosal immunity
title_short NALT- versus PEYER'S-patch-mediated mucosal immunity
title_sort nalt- versus peyer's-patch-mediated mucosal immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097243/
https://www.ncbi.nlm.nih.gov/pubmed/15343369
http://dx.doi.org/10.1038/nri1439
work_keys_str_mv AT kiyonohiroshi naltversuspeyerspatchmediatedmucosalimmunity
AT fukuyamasatoshi naltversuspeyerspatchmediatedmucosalimmunity

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