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Immunopathogenesis of coronavirus infections: implications for SARS
At the end of 2002, the first cases of severe acute respiratory syndrome (SARS) were reported, and in the following year, SARS resulted in considerable mortality and morbidity worldwide. SARS is caused by a novel species of coronavirus (SARS-CoV) and is the most severe coronavirus-mediated human dis...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097326/ https://www.ncbi.nlm.nih.gov/pubmed/16322745 http://dx.doi.org/10.1038/nri1732 |
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author | Dandekar, Ajai A. Perlman, Stanley |
author_facet | Dandekar, Ajai A. Perlman, Stanley |
author_sort | Dandekar, Ajai A. |
collection | PubMed |
description | At the end of 2002, the first cases of severe acute respiratory syndrome (SARS) were reported, and in the following year, SARS resulted in considerable mortality and morbidity worldwide. SARS is caused by a novel species of coronavirus (SARS-CoV) and is the most severe coronavirus-mediated human disease that has been described so far. On the basis of similarities with other coronavirus infections, SARS might, in part, be immune mediated. As discussed in this Review, studies of animals that are infected with other coronaviruses indicate that excessive and sometimes dysregulated responses by macrophages and other pro-inflammatory cells might be particularly important in the pathogenesis of disease that is caused by infection with these viruses. It is hoped that lessons from such studies will help us to understand more about the pathogenesis of SARS in humans and to prevent or control outbreaks of SARS in the future. |
format | Online Article Text |
id | pubmed-7097326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70973262020-03-26 Immunopathogenesis of coronavirus infections: implications for SARS Dandekar, Ajai A. Perlman, Stanley Nat Rev Immunol Article At the end of 2002, the first cases of severe acute respiratory syndrome (SARS) were reported, and in the following year, SARS resulted in considerable mortality and morbidity worldwide. SARS is caused by a novel species of coronavirus (SARS-CoV) and is the most severe coronavirus-mediated human disease that has been described so far. On the basis of similarities with other coronavirus infections, SARS might, in part, be immune mediated. As discussed in this Review, studies of animals that are infected with other coronaviruses indicate that excessive and sometimes dysregulated responses by macrophages and other pro-inflammatory cells might be particularly important in the pathogenesis of disease that is caused by infection with these viruses. It is hoped that lessons from such studies will help us to understand more about the pathogenesis of SARS in humans and to prevent or control outbreaks of SARS in the future. Nature Publishing Group UK 2005 /pmc/articles/PMC7097326/ /pubmed/16322745 http://dx.doi.org/10.1038/nri1732 Text en © Nature Publishing Group 2005 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Dandekar, Ajai A. Perlman, Stanley Immunopathogenesis of coronavirus infections: implications for SARS |
title | Immunopathogenesis of coronavirus infections: implications for SARS |
title_full | Immunopathogenesis of coronavirus infections: implications for SARS |
title_fullStr | Immunopathogenesis of coronavirus infections: implications for SARS |
title_full_unstemmed | Immunopathogenesis of coronavirus infections: implications for SARS |
title_short | Immunopathogenesis of coronavirus infections: implications for SARS |
title_sort | immunopathogenesis of coronavirus infections: implications for sars |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097326/ https://www.ncbi.nlm.nih.gov/pubmed/16322745 http://dx.doi.org/10.1038/nri1732 |
work_keys_str_mv | AT dandekarajaia immunopathogenesisofcoronavirusinfectionsimplicationsforsars AT perlmanstanley immunopathogenesisofcoronavirusinfectionsimplicationsforsars |