Cargando…

RNA viruses: hijacking the dynamic nucleolus

The nucleolus is a dynamic subnuclear structure with roles in ribosome subunit biogenesis, mediation of cell-stress responses and regulation of cell growth. The proteome and structure of the nucleolus are constantly changing in response to metabolic conditions. RNA viruses interact with the nucleolu...

Descripción completa

Detalles Bibliográficos
Autor principal: Hiscox, Julian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097444/
https://www.ncbi.nlm.nih.gov/pubmed/17224921
http://dx.doi.org/10.1038/nrmicro1597
_version_ 1783511002492436480
author Hiscox, Julian A.
author_facet Hiscox, Julian A.
author_sort Hiscox, Julian A.
collection PubMed
description The nucleolus is a dynamic subnuclear structure with roles in ribosome subunit biogenesis, mediation of cell-stress responses and regulation of cell growth. The proteome and structure of the nucleolus are constantly changing in response to metabolic conditions. RNA viruses interact with the nucleolus to usurp host-cell functions and recruit nucleolar proteins to facilitate virus replication. Investigating the interactions between RNA viruses and the nucleolus will facilitate the design of novel anti-viral therapies, such as recombinant vaccines and therapeutic molecular interventions, and also contribute to a more detailed understanding of the cell biology of the nucleolus.
format Online
Article
Text
id pubmed-7097444
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-70974442020-03-26 RNA viruses: hijacking the dynamic nucleolus Hiscox, Julian A. Nat Rev Microbiol Article The nucleolus is a dynamic subnuclear structure with roles in ribosome subunit biogenesis, mediation of cell-stress responses and regulation of cell growth. The proteome and structure of the nucleolus are constantly changing in response to metabolic conditions. RNA viruses interact with the nucleolus to usurp host-cell functions and recruit nucleolar proteins to facilitate virus replication. Investigating the interactions between RNA viruses and the nucleolus will facilitate the design of novel anti-viral therapies, such as recombinant vaccines and therapeutic molecular interventions, and also contribute to a more detailed understanding of the cell biology of the nucleolus. Nature Publishing Group UK 2007 /pmc/articles/PMC7097444/ /pubmed/17224921 http://dx.doi.org/10.1038/nrmicro1597 Text en © Nature Publishing Group 2007 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Hiscox, Julian A.
RNA viruses: hijacking the dynamic nucleolus
title RNA viruses: hijacking the dynamic nucleolus
title_full RNA viruses: hijacking the dynamic nucleolus
title_fullStr RNA viruses: hijacking the dynamic nucleolus
title_full_unstemmed RNA viruses: hijacking the dynamic nucleolus
title_short RNA viruses: hijacking the dynamic nucleolus
title_sort rna viruses: hijacking the dynamic nucleolus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097444/
https://www.ncbi.nlm.nih.gov/pubmed/17224921
http://dx.doi.org/10.1038/nrmicro1597
work_keys_str_mv AT hiscoxjuliana rnaviruseshijackingthedynamicnucleolus