Architecture of the SARS coronavirus prefusion spike

The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 's...

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Detalles Bibliográficos
Autores principales: Beniac, Daniel R, Andonov, Anton, Grudeski, Elsie, Booth, Tim F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097490/
https://www.ncbi.nlm.nih.gov/pubmed/16845391
http://dx.doi.org/10.1038/nsmb1123
Descripción
Sumario:The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nsmb1123) contains supplementary material, which is available to authorized users.

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