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Toll-like receptors in systemic autoimmune disease
Toll-like receptors (TLRs) have a crucial role in the early detection of pathogen-associated molecular patterns and the subsequent activation of the adaptive immune response. Whether TLRs also have an important role in the recognition of endogenous ligands has been more controversial. Numerous in vi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097510/ https://www.ncbi.nlm.nih.gov/pubmed/17063184 http://dx.doi.org/10.1038/nri1957 |
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author | Marshak-Rothstein, Ann |
author_facet | Marshak-Rothstein, Ann |
author_sort | Marshak-Rothstein, Ann |
collection | PubMed |
description | Toll-like receptors (TLRs) have a crucial role in the early detection of pathogen-associated molecular patterns and the subsequent activation of the adaptive immune response. Whether TLRs also have an important role in the recognition of endogenous ligands has been more controversial. Numerous in vitro studies have documented activation of both autoreactive B cells and plasmacytoid dendritic cells by mammalian TLR ligands. The issue of whether these in vitro observations translate to an in vivo role for TLRs in either the initiation or the progression of systemic autoimmune disease is a subject of intense research; data are beginning to emerge showing that this is the case. |
format | Online Article Text |
id | pubmed-7097510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70975102020-03-26 Toll-like receptors in systemic autoimmune disease Marshak-Rothstein, Ann Nat Rev Immunol Article Toll-like receptors (TLRs) have a crucial role in the early detection of pathogen-associated molecular patterns and the subsequent activation of the adaptive immune response. Whether TLRs also have an important role in the recognition of endogenous ligands has been more controversial. Numerous in vitro studies have documented activation of both autoreactive B cells and plasmacytoid dendritic cells by mammalian TLR ligands. The issue of whether these in vitro observations translate to an in vivo role for TLRs in either the initiation or the progression of systemic autoimmune disease is a subject of intense research; data are beginning to emerge showing that this is the case. Nature Publishing Group UK 2006 /pmc/articles/PMC7097510/ /pubmed/17063184 http://dx.doi.org/10.1038/nri1957 Text en © Nature Publishing Group 2006 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Marshak-Rothstein, Ann Toll-like receptors in systemic autoimmune disease |
title | Toll-like receptors in systemic autoimmune disease |
title_full | Toll-like receptors in systemic autoimmune disease |
title_fullStr | Toll-like receptors in systemic autoimmune disease |
title_full_unstemmed | Toll-like receptors in systemic autoimmune disease |
title_short | Toll-like receptors in systemic autoimmune disease |
title_sort | toll-like receptors in systemic autoimmune disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097510/ https://www.ncbi.nlm.nih.gov/pubmed/17063184 http://dx.doi.org/10.1038/nri1957 |
work_keys_str_mv | AT marshakrothsteinann tolllikereceptorsinsystemicautoimmunedisease |