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Toll-like receptors in systemic autoimmune disease

Toll-like receptors (TLRs) have a crucial role in the early detection of pathogen-associated molecular patterns and the subsequent activation of the adaptive immune response. Whether TLRs also have an important role in the recognition of endogenous ligands has been more controversial. Numerous in vi...

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Autor principal: Marshak-Rothstein, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097510/
https://www.ncbi.nlm.nih.gov/pubmed/17063184
http://dx.doi.org/10.1038/nri1957
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author Marshak-Rothstein, Ann
author_facet Marshak-Rothstein, Ann
author_sort Marshak-Rothstein, Ann
collection PubMed
description Toll-like receptors (TLRs) have a crucial role in the early detection of pathogen-associated molecular patterns and the subsequent activation of the adaptive immune response. Whether TLRs also have an important role in the recognition of endogenous ligands has been more controversial. Numerous in vitro studies have documented activation of both autoreactive B cells and plasmacytoid dendritic cells by mammalian TLR ligands. The issue of whether these in vitro observations translate to an in vivo role for TLRs in either the initiation or the progression of systemic autoimmune disease is a subject of intense research; data are beginning to emerge showing that this is the case.
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spelling pubmed-70975102020-03-26 Toll-like receptors in systemic autoimmune disease Marshak-Rothstein, Ann Nat Rev Immunol Article Toll-like receptors (TLRs) have a crucial role in the early detection of pathogen-associated molecular patterns and the subsequent activation of the adaptive immune response. Whether TLRs also have an important role in the recognition of endogenous ligands has been more controversial. Numerous in vitro studies have documented activation of both autoreactive B cells and plasmacytoid dendritic cells by mammalian TLR ligands. The issue of whether these in vitro observations translate to an in vivo role for TLRs in either the initiation or the progression of systemic autoimmune disease is a subject of intense research; data are beginning to emerge showing that this is the case. Nature Publishing Group UK 2006 /pmc/articles/PMC7097510/ /pubmed/17063184 http://dx.doi.org/10.1038/nri1957 Text en © Nature Publishing Group 2006 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Marshak-Rothstein, Ann
Toll-like receptors in systemic autoimmune disease
title Toll-like receptors in systemic autoimmune disease
title_full Toll-like receptors in systemic autoimmune disease
title_fullStr Toll-like receptors in systemic autoimmune disease
title_full_unstemmed Toll-like receptors in systemic autoimmune disease
title_short Toll-like receptors in systemic autoimmune disease
title_sort toll-like receptors in systemic autoimmune disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097510/
https://www.ncbi.nlm.nih.gov/pubmed/17063184
http://dx.doi.org/10.1038/nri1957
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