Metalloproteinases in biology and pathology of the nervous system

Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous system. Here we review the evidence that supports this idea and discuss the possible mechanisms of MMP action. We then consider some of the beneficial functions of MMPs during neural development and speculate on...

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Detalles Bibliográficos
Autores principales: Yong, V. Wee, Power, Christopher, Forsyth, Peter, Edwards, Dylan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097548/
https://www.ncbi.nlm.nih.gov/pubmed/11433375
http://dx.doi.org/10.1038/35081571
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author Yong, V. Wee
Power, Christopher
Forsyth, Peter
Edwards, Dylan R.
author_facet Yong, V. Wee
Power, Christopher
Forsyth, Peter
Edwards, Dylan R.
author_sort Yong, V. Wee
collection PubMed
description Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous system. Here we review the evidence that supports this idea and discuss the possible mechanisms of MMP action. We then consider some of the beneficial functions of MMPs during neural development and speculate on their roles in repair after brain injury. We also introduce a family of proteins known as ADAMs (a disintegrin and metalloproteinase), as some of the properties previously ascribed to MMPs are possibly the result of ADAM activity.
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spelling pubmed-70975482020-03-26 Metalloproteinases in biology and pathology of the nervous system Yong, V. Wee Power, Christopher Forsyth, Peter Edwards, Dylan R. Nat Rev Neurosci Article Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous system. Here we review the evidence that supports this idea and discuss the possible mechanisms of MMP action. We then consider some of the beneficial functions of MMPs during neural development and speculate on their roles in repair after brain injury. We also introduce a family of proteins known as ADAMs (a disintegrin and metalloproteinase), as some of the properties previously ascribed to MMPs are possibly the result of ADAM activity. Nature Publishing Group UK 2001 /pmc/articles/PMC7097548/ /pubmed/11433375 http://dx.doi.org/10.1038/35081571 Text en © Nature Publishing Group 2001 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Yong, V. Wee
Power, Christopher
Forsyth, Peter
Edwards, Dylan R.
Metalloproteinases in biology and pathology of the nervous system
title Metalloproteinases in biology and pathology of the nervous system
title_full Metalloproteinases in biology and pathology of the nervous system
title_fullStr Metalloproteinases in biology and pathology of the nervous system
title_full_unstemmed Metalloproteinases in biology and pathology of the nervous system
title_short Metalloproteinases in biology and pathology of the nervous system
title_sort metalloproteinases in biology and pathology of the nervous system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097548/
https://www.ncbi.nlm.nih.gov/pubmed/11433375
http://dx.doi.org/10.1038/35081571
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