Cargando…

Knocking down barriers: advances in siRNA delivery

In the 10 years that have passed since the Nobel prize-winning discovery of RNA interference (RNAi), billions of dollars have been invested in the therapeutic application of gene silencing in humans. Today, there are promising data from ongoing clinical trials for the treatment of age-related macula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Whitehead, Kathryn A., Langer, Robert, Anderson, Daniel G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097568/ https://www.ncbi.nlm.nih.gov/pubmed/19180106 http://dx.doi.org/10.1038/nrd2742

Ejemplares similares

Knocking down Disease with siRNAs
por: Dykxhoorn, Derek M., et al.
Publicado: (2006)

Knock-down of ELMO1 in Paediatric Rhabdomyosarcoma Cells by Nanoparticle Mediated siRNA Delivery
por: Huang, Xinyue, et al.
Publicado: (2016)

Degradable Lipid Nanoparticles with Predictable In Vivo siRNA Delivery Activity
por: Whitehead, Kathryn A., et al.
Publicado: (2014)

Gold Nanoparticle Mediated Laser Transfection for Efficient siRNA Mediated Gene Knock Down
por: Heinemann, Dag, et al.
Publicado: (2013)

Oral delivery of siRNA lipid nanoparticles: Fate in the GI tract
por: Ball, Rebecca L., et al.
Publicado: (2018)

Knocking Down TMPRSS2-ERG Fusion Oncogene by siRNA Could be an Alternative Treatment to Flutamide
por: Urbinati, Giorgia, et al.
Publicado: (2016)

Advances in Lipid Nanoparticles for siRNA Delivery
por: Tam, Yuen Yi C., et al.
Publicado: (2013)

In vitro and intrathecal siRNA mediated K(V)1.1 knock-down in primary sensory neurons
por: Baker, Mark D., et al.
Publicado: (2011)

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
por: Sahay, Gaurav, et al.
Publicado: (2013)

Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down
por: Costa, José L, et al.
Publicado: (2009)

Targeted Delivery of siRNA
por: Oliveira, Sabrina, et al.
Publicado: (2006)

Dendrimers for siRNA Delivery
por: Biswas, Swati, et al.
Publicado: (2013)

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins
por: Yang, Nicole J., et al.
Publicado: (2017)

Recombinant Adenovirus siRNA Knocking Down the Ndufs4 Gene Alleviates Myocardial Apoptosis Induced by Oxidative Stress Injury
por: Wang, Beibei, et al.
Publicado: (2023)

A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery
por: Lu, James J., et al.
Publicado: (2009)

Acetylation of PAMAM dendrimers for cellular delivery of siRNA
por: Waite, Carolyn L, et al.
Publicado: (2009)

Aptamer mediated siRNA delivery
por: Chu, Ted C., et al.
Publicado: (2006)

Pulmonary delivery of therapeutic siRNA
por: Lam, Jenny Ka-Wing, et al.
Publicado: (2012)

Intranasal Delivery of Antiviral siRNA
por: Barik, Sailen
Publicado: (2010)

Drug Delivery of siRNA Therapeutics
por: Lamberti, Gaetano, et al.
Publicado: (2020)

Lipidoid Nanoparticles for siRNA Delivery to the Intestinal Epithelium: In Vitro Investigations in a Caco-2 Model
por: Ball, Rebecca L., et al.
Publicado: (2015)

Amphiphilic Peptides for Efficient siRNA Delivery
por: Mozaffari, Saghar, et al.
Publicado: (2019)

Chaperonin–Dendrimer Conjugates for siRNA Delivery
por: Nussbaumer, Martin G., et al.
Publicado: (2016)

WDR7 up-regulation upon knocking down of neighboring non-coding RNA using siRNAs encapsulated in polyamidoamine dendrimers
por: Kor, Sara, et al.
Publicado: (2019)

Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer
por: Escalona, Ruth M., et al.
Publicado: (2022)

Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles
por: Khan, Omar F., et al.
Publicado: (2018)

BBB pathophysiology–independent delivery of siRNA in traumatic brain injury
por: Li, Wen, et al.
Publicado: (2021)

Recent advances in siRNA delivery mediated by lipid-based nanoparticles
por: Yonezawa, Sei, et al.
Publicado: (2020)

Advances with Lipid-Based Nanosystems for siRNA Delivery to Breast Cancers
por: Subhan, Md Abdus, et al.
Publicado: (2023)

Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo siRNA Delivery
por: Lee, Hyukjin, et al.
Publicado: (2012)

Centyrin ligands for extrahepatic delivery of siRNA
por: Klein, Donna, et al.
Publicado: (2021)

Albumin pre-coating enhances intracellular siRNA delivery of multifunctional amphiphile/siRNA nanoparticles
por: Kummitha, China M, et al.
Publicado: (2012)

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
por: Foster, Donald J., et al.
Publicado: (2018)

Bone site-specific delivery of siRNA
por: Liu, Xinli
Publicado: (2016)

Non-viral siRNA delivery to the lung()
por: Thomas, Mini, et al.
Publicado: (2007)

Nanoscale Particles for Lung Delivery of siRNA
por: Nascimento, T.L., et al.
Publicado: (2012)

Knocking-Down Cyclin A(2) by siRNA Suppresses Apoptosis and Switches Differentiation Pathways in K562 Cells upon Administration with Doxorubicin
por: Wang, Xiaohui, et al.
Publicado: (2009)

Combining the chemotherapeutic effects of epigallocatechin 3-gallate with siRNA-mediated p53 knock-down results in synergic pro-apoptotic effects
por: Berindan-Neagoe, Ioana, et al.
Publicado: (2012)

BSA Nanoparticles for siRNA Delivery: Coating Effects on Nanoparticle Properties, Plasma Protein Adsorption, and In Vitro siRNA Delivery
por: Yogasundaram, Haran, et al.
Publicado: (2012)

Molecular Umbrella Conjugate for the Ocular Delivery of siRNA
por: Janout, Vaclav, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vdnl062la0uji7426ok0j3n9d3