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The interplay of extracellular matrix and microbiome in urothelial bladder cancer

Many pathological changes in solid tumours are caused by the accumulation of genetic mutations and epigenetic molecular alterations. In addition, tumour progression is profoundly influenced by the environment surrounding the transformed cells. The interplay between tumour cells and their microenviro...

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Autores principales: Alfano, Massimo, Canducci, Filippo, Nebuloni, Manuela, Clementi, Massimo, Montorsi, Francesco, Salonia, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097604/
https://www.ncbi.nlm.nih.gov/pubmed/26666363
http://dx.doi.org/10.1038/nrurol.2015.292
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author Alfano, Massimo
Canducci, Filippo
Nebuloni, Manuela
Clementi, Massimo
Montorsi, Francesco
Salonia, Andrea
author_facet Alfano, Massimo
Canducci, Filippo
Nebuloni, Manuela
Clementi, Massimo
Montorsi, Francesco
Salonia, Andrea
author_sort Alfano, Massimo
collection PubMed
description Many pathological changes in solid tumours are caused by the accumulation of genetic mutations and epigenetic molecular alterations. In addition, tumour progression is profoundly influenced by the environment surrounding the transformed cells. The interplay between tumour cells and their microenvironment has been recognized as one of the key determinants of cancer development and is being extensively investigated. Data suggest that both the extracellular matrix and the microbiota represent microenvironments that contribute to the onset and progression of tumours. Through the introduction of omics technologies and pyrosequencing analyses, a detailed investigation of these two microenvironments is now possible. In urological research, assessment of their dysregulation has become increasingly important to provide diagnostic, prognostic and predictive biomarkers for urothelial bladder cancer. Understanding the roles of the extracellular matrix and microbiota, two key components of the urothelial mucosa, in the sequelae of pathogenic events that occur in the development and progression of urothelial carcinomas will be important to overcome the shortcomings in current bladder cancer treatment strategies. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nrurol.2015.292) contains supplementary material, which is available to authorized users.
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spelling pubmed-70976042020-03-26 The interplay of extracellular matrix and microbiome in urothelial bladder cancer Alfano, Massimo Canducci, Filippo Nebuloni, Manuela Clementi, Massimo Montorsi, Francesco Salonia, Andrea Nat Rev Urol Article Many pathological changes in solid tumours are caused by the accumulation of genetic mutations and epigenetic molecular alterations. In addition, tumour progression is profoundly influenced by the environment surrounding the transformed cells. The interplay between tumour cells and their microenvironment has been recognized as one of the key determinants of cancer development and is being extensively investigated. Data suggest that both the extracellular matrix and the microbiota represent microenvironments that contribute to the onset and progression of tumours. Through the introduction of omics technologies and pyrosequencing analyses, a detailed investigation of these two microenvironments is now possible. In urological research, assessment of their dysregulation has become increasingly important to provide diagnostic, prognostic and predictive biomarkers for urothelial bladder cancer. Understanding the roles of the extracellular matrix and microbiota, two key components of the urothelial mucosa, in the sequelae of pathogenic events that occur in the development and progression of urothelial carcinomas will be important to overcome the shortcomings in current bladder cancer treatment strategies. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nrurol.2015.292) contains supplementary material, which is available to authorized users. Nature Publishing Group UK 2015-12-15 2016 /pmc/articles/PMC7097604/ /pubmed/26666363 http://dx.doi.org/10.1038/nrurol.2015.292 Text en © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2015 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Alfano, Massimo
Canducci, Filippo
Nebuloni, Manuela
Clementi, Massimo
Montorsi, Francesco
Salonia, Andrea
The interplay of extracellular matrix and microbiome in urothelial bladder cancer
title The interplay of extracellular matrix and microbiome in urothelial bladder cancer
title_full The interplay of extracellular matrix and microbiome in urothelial bladder cancer
title_fullStr The interplay of extracellular matrix and microbiome in urothelial bladder cancer
title_full_unstemmed The interplay of extracellular matrix and microbiome in urothelial bladder cancer
title_short The interplay of extracellular matrix and microbiome in urothelial bladder cancer
title_sort interplay of extracellular matrix and microbiome in urothelial bladder cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097604/
https://www.ncbi.nlm.nih.gov/pubmed/26666363
http://dx.doi.org/10.1038/nrurol.2015.292
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