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Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A(2)
A lead compound obtained from a high volume human non-pancreatic secretory phospholipase A(2) (hnps-PLA(2)) screen has been developed into a potent inhibitor using detailed structural knowledge of inhibitor binding to the enzyme active site. Four crystal structures of hnps-PLA(2) complexed with a se...
Autores principales: | Schevitz, R.W., Bach, N.J., Carlson, D.G., Chirgadze, N.Y., Clawson, D.K., Dillard, R.D., Draheim, S.E., Hartley, L.W., Jones, N.D., Mihelich, E.D., Olkowski, J.L., Snyder, D.W., Sommers, C., Wery, J.-P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
1995
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097651/ https://www.ncbi.nlm.nih.gov/pubmed/7664108 http://dx.doi.org/10.1038/nsb0695-458 |
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