Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A(2)

A lead compound obtained from a high volume human non-pancreatic secretory phospholipase A(2) (hnps-PLA(2)) screen has been developed into a potent inhibitor using detailed structural knowledge of inhibitor binding to the enzyme active site. Four crystal structures of hnps-PLA(2) complexed with a se...

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Detalles Bibliográficos
Autores principales: Schevitz, R.W., Bach, N.J., Carlson, D.G., Chirgadze, N.Y., Clawson, D.K., Dillard, R.D., Draheim, S.E., Hartley, L.W., Jones, N.D., Mihelich, E.D., Olkowski, J.L., Snyder, D.W., Sommers, C., Wery, J.-P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 1995
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097651/
https://www.ncbi.nlm.nih.gov/pubmed/7664108
http://dx.doi.org/10.1038/nsb0695-458

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