Cargando…
Discriminating self from non-self in nucleic acid sensing
Innate immunity against pathogens relies on an array of immune receptors to detect molecular patterns that are characteristic of the pathogens, including receptors that are specialized in the detection of foreign nucleic acids. In vertebrates, nucleic acid sensing is the dominant antiviral defence p...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097691/ https://www.ncbi.nlm.nih.gov/pubmed/27455396 http://dx.doi.org/10.1038/nri.2016.78 |
_version_ | 1783511037785407488 |
---|---|
author | Schlee, Martin Hartmann, Gunther |
author_facet | Schlee, Martin Hartmann, Gunther |
author_sort | Schlee, Martin |
collection | PubMed |
description | Innate immunity against pathogens relies on an array of immune receptors to detect molecular patterns that are characteristic of the pathogens, including receptors that are specialized in the detection of foreign nucleic acids. In vertebrates, nucleic acid sensing is the dominant antiviral defence pathway. Stimulation of nucleic acid receptors results in antiviral immune responses with the production of type I interferon (IFN), as well as the expression of IFN-stimulated genes, which encode molecules such as cell-autonomous antiviral effector proteins. This Review summarizes the tremendous progress that has been made in understanding how this sophisticated immune sensory system discriminates self from non-self nucleic acids in order to reliably detect pathogenic viruses. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nri.2016.78) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7097691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70976912020-03-26 Discriminating self from non-self in nucleic acid sensing Schlee, Martin Hartmann, Gunther Nat Rev Immunol Article Innate immunity against pathogens relies on an array of immune receptors to detect molecular patterns that are characteristic of the pathogens, including receptors that are specialized in the detection of foreign nucleic acids. In vertebrates, nucleic acid sensing is the dominant antiviral defence pathway. Stimulation of nucleic acid receptors results in antiviral immune responses with the production of type I interferon (IFN), as well as the expression of IFN-stimulated genes, which encode molecules such as cell-autonomous antiviral effector proteins. This Review summarizes the tremendous progress that has been made in understanding how this sophisticated immune sensory system discriminates self from non-self nucleic acids in order to reliably detect pathogenic viruses. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nri.2016.78) contains supplementary material, which is available to authorized users. Nature Publishing Group UK 2016-07-25 2016 /pmc/articles/PMC7097691/ /pubmed/27455396 http://dx.doi.org/10.1038/nri.2016.78 Text en © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Schlee, Martin Hartmann, Gunther Discriminating self from non-self in nucleic acid sensing |
title | Discriminating self from non-self in nucleic acid sensing |
title_full | Discriminating self from non-self in nucleic acid sensing |
title_fullStr | Discriminating self from non-self in nucleic acid sensing |
title_full_unstemmed | Discriminating self from non-self in nucleic acid sensing |
title_short | Discriminating self from non-self in nucleic acid sensing |
title_sort | discriminating self from non-self in nucleic acid sensing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097691/ https://www.ncbi.nlm.nih.gov/pubmed/27455396 http://dx.doi.org/10.1038/nri.2016.78 |
work_keys_str_mv | AT schleemartin discriminatingselffromnonselfinnucleicacidsensing AT hartmanngunther discriminatingselffromnonselfinnucleicacidsensing |