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Discriminating self from non-self in nucleic acid sensing

Innate immunity against pathogens relies on an array of immune receptors to detect molecular patterns that are characteristic of the pathogens, including receptors that are specialized in the detection of foreign nucleic acids. In vertebrates, nucleic acid sensing is the dominant antiviral defence p...

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Detalles Bibliográficos
Autores principales: Schlee, Martin, Hartmann, Gunther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097691/
https://www.ncbi.nlm.nih.gov/pubmed/27455396
http://dx.doi.org/10.1038/nri.2016.78
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author Schlee, Martin
Hartmann, Gunther
author_facet Schlee, Martin
Hartmann, Gunther
author_sort Schlee, Martin
collection PubMed
description Innate immunity against pathogens relies on an array of immune receptors to detect molecular patterns that are characteristic of the pathogens, including receptors that are specialized in the detection of foreign nucleic acids. In vertebrates, nucleic acid sensing is the dominant antiviral defence pathway. Stimulation of nucleic acid receptors results in antiviral immune responses with the production of type I interferon (IFN), as well as the expression of IFN-stimulated genes, which encode molecules such as cell-autonomous antiviral effector proteins. This Review summarizes the tremendous progress that has been made in understanding how this sophisticated immune sensory system discriminates self from non-self nucleic acids in order to reliably detect pathogenic viruses. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nri.2016.78) contains supplementary material, which is available to authorized users.
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spelling pubmed-70976912020-03-26 Discriminating self from non-self in nucleic acid sensing Schlee, Martin Hartmann, Gunther Nat Rev Immunol Article Innate immunity against pathogens relies on an array of immune receptors to detect molecular patterns that are characteristic of the pathogens, including receptors that are specialized in the detection of foreign nucleic acids. In vertebrates, nucleic acid sensing is the dominant antiviral defence pathway. Stimulation of nucleic acid receptors results in antiviral immune responses with the production of type I interferon (IFN), as well as the expression of IFN-stimulated genes, which encode molecules such as cell-autonomous antiviral effector proteins. This Review summarizes the tremendous progress that has been made in understanding how this sophisticated immune sensory system discriminates self from non-self nucleic acids in order to reliably detect pathogenic viruses. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nri.2016.78) contains supplementary material, which is available to authorized users. Nature Publishing Group UK 2016-07-25 2016 /pmc/articles/PMC7097691/ /pubmed/27455396 http://dx.doi.org/10.1038/nri.2016.78 Text en © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Schlee, Martin
Hartmann, Gunther
Discriminating self from non-self in nucleic acid sensing
title Discriminating self from non-self in nucleic acid sensing
title_full Discriminating self from non-self in nucleic acid sensing
title_fullStr Discriminating self from non-self in nucleic acid sensing
title_full_unstemmed Discriminating self from non-self in nucleic acid sensing
title_short Discriminating self from non-self in nucleic acid sensing
title_sort discriminating self from non-self in nucleic acid sensing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097691/
https://www.ncbi.nlm.nih.gov/pubmed/27455396
http://dx.doi.org/10.1038/nri.2016.78
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